| Primary distal renal tubular acidosis as a result of a gradient defect. | |
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MedLine Citation:
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PMID: 8604714 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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It has been generally accepted that primary distal renal tubular acidosis (DRTA) is the result of a defect in proton secretion in the distal nephron (secretory defect). We report an infant with DRTA, evidenced by spontaneous hyperchloremic metabolic acidosis with low urinary ammonium excretion rate and inability to decrease urine pH during acidosis, who nevertheless exhibited an intact ability to increase urinary carbon dioxide partial pressure (pCO2) during maximal urine alkalinization and normal ability to acidify the urine after furosemide, suggestive of a gradient-type defect DRTA. This patient had never been exposed to amphotericin B. To our knowledge, this is the first fully documented report of primary DRTA that can be attributed to gradient defect. |
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Authors:
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M Bonilla-Felix |
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Publication Detail:
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Type: Case Reports; Journal Article; Review |
Journal Detail:
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Title: American journal of kidney diseases : the official journal of the National Kidney Foundation Volume: 27 ISSN: 0272-6386 ISO Abbreviation: Am. J. Kidney Dis. Publication Date: 1996 Mar |
Date Detail:
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Created Date: 1996-05-14 Completed Date: 1996-05-14 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8110075 Medline TA: Am J Kidney Dis Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 428-30 Citation Subset: IM |
Affiliation:
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Division of Pediatric Nephrology, Department of Pediatrics, University of Texas-Health Science Center at Houston, TX 77030, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acetazolamide
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diagnostic use Acidosis, Renal Tubular / blood, diagnosis, etiology*, urine Carbon Dioxide Diuretics / diagnostic use Furosemide / diagnostic use Humans Hydrogen-Ion Concentration Infant Male Partial Pressure Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Diuretics; 124-38-9/Carbon Dioxide; 54-31-9/Furosemide; 59-66-5/Acetazolamide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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