Document Detail

Primary diffuse large B-cell lymphoma of the corpora cavernosa presented as a perineal mass.
Jump to Full Text
MedLine Citation:
PMID:  22919138     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Primary male genital lymphomas may appear rarely in testis, and exceptionally in the penis and prostate, but there is not previous evidence of a lymphoma arising from the corpora cavernosa. We report the first case in the literature of a primary diffuse cell B lymphoma of the corpora cavernosa presented with low urinary tract symptoms, perineal pain and palpable mass. Diagnosis was based on trucut biopsy, histopathological studies and computed tomographic images.
González-Satué Carlos; Valverde Vilamala Ivanna; Tapia Melendo Gustavo; Areal Calama Joan; Sanchez Macias Javier; Ibarz Servio Luis
Related Documents :
22716318 - Heterotopic glioneuronal mass of the cerebellomedullary cistern with duct cyst formatio...
6232128 - Laparoscopic splenic biopsy.
6768238 - Increased echogenicity of the spleen in benign and malignant disease.
2208008 - Flow cytometric dna analysis of parathyroid tumors. implication of aneuploidy for patho...
16327458 - Endoscopic removal of dermoid cysts of the eyebrow in pediatric patients.
21417868 - Diagnostic methods for fungal infections in pediatric patients: microbiological, serolo...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Indian journal of urology : IJU : journal of the Urological Society of India     Volume:  28     ISSN:  1998-3824     ISO Abbreviation:  Indian J Urol     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-08-24     Completed Date:  2012-08-24     Revised Date:  2013-05-30    
Medline Journal Info:
Nlm Unique ID:  8510441     Medline TA:  Indian J Urol     Country:  India    
Other Details:
Languages:  eng     Pagination:  196-8     Citation Subset:  -    
Department of Urology, Germans Trias i Pujol Hospital, Badalona, Barcelona, Spain.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Full Text
Journal Information
Journal ID (nlm-ta): Indian J Urol
Journal ID (iso-abbrev): Indian J Urol
Journal ID (publisher-id): IJU
ISSN: 0970-1591
ISSN: 1998-3824
Publisher: Medknow Publications & Media Pvt Ltd, India
Article Information
Copyright: © Indian Journal of Urology
Print publication date: Season: Apr-Jun Year: 2012
Volume: 28 Issue: 2
First Page: 196 Last Page: 198
ID: 3424899
PubMed Id: 22919138
Publisher Id: IJU-28-196
DOI: 10.4103/0970-1591.98465

Primary diffuse large B-cell lymphoma of the corpora cavernosa presented as a perineal mass
González-Satué Carlosaff1
Valverde Vilamala Ivannaaff1
Tapia Melendo Gustavo1
Areal Calama Joanaff1
Sanchez Macias Javieraff1
Ibarz Servio Luisaff1
Department of Urology, Germans Trias i Pujol Hospital, Badalona, Barcelona, Spain
1Department of Pathology, Germans Trias i Pujol Hospital, Badalona, Barcelona, Spain
Correspondence: For correspondence: Dr. González-Satué Carlos, Urology Department, Germans Trias I Pujol Hospital (9th floor). Crta canyet s/n, 08916, Badalona, Barcelona, Spain. E-mail:


Urologic extranodal lymphomas are infrequent, presenting less than 5% of primary extranodal lymphomas. Urologic lymphomas are mainly located in the kidney or the bladder.[1] In male, genital lymphomas are usually testicular, and rarely penile or prostatic. Corpora cavernosa lymphomas only appear in the literature as a secondary involvement of a primary lymphoma of the penis.[2] No evidence for any type of primary lymphoma to arise from the corpora cavernosa without penile involvement has been reported so far. Because extranodal lymphomas tend to behave aggressively, treatment of diffuse B-cell lymphomas is usually rituximab-based chemotherapy with local excision when possible.[3] Extern beam radiation may also be used in selected cases. Clinical presentation of perineal masses are not characteristic; therefore diagnosis is often performed too late.


A 65-year-old man with pathological history of peripheral vasculopathy, Leriche syndrome, and bearing a cardiac pacemaker, presented a 3-month history of dysuria, weak urinary flow, progressive voiding discomfort, and perineal pain, when a perineal swelling that was slowly growing was detected. Physical examination showed normal external genitalia and a painful 4-cm perineoescrotal mass in contact with the bulbar urethra. Digital rectal examination detected a small and nonsuspicious prostate.

The patient was examined via ultrasonography. A 15-cc heterogeneous prostate was detected with 85 cc of postvoiding residual urine. Voiding cistourethrography showed a slight narrowing of the diameter of the bulbar urethra, but not a significant urethral stricture, suggesting an external compression of the urethra. PSA blood level was 0.56 ng/ml, erythrocyte sedimentation rate was 21 sec, and urinary culture was negative.

Multiple trucut transperineal biopsies of the mass were performed under 7 Mhz ultrasonography guidance. The histopathological examination of a core biopsy showed a diffuse, dense infiltrate of atypical large lymphoid cells with frequent mitotic figures [Figure 1]. Immunohistochemical studies showed the cells to be positive for B-cell marker (CD20) and negative for T-cell markers (CD3 and CD5), CD10, and BCL6. The proliferative index (Ki 67) was 70%. Based on these findings, a diagnosis of diffuse large B-cell lymphoma was delivered.

A thoracic-abdomino-pelvic computer tomography (CT) was prescribed in order to search for a primary nodal origin of the lymphoma. Findings of the CT were as follows: absence of mesenteric, retroperitoneal, or pelvic significant nodes, at the CT sagital section, the anatomy of corpora cavernosa is replaced by a heterogeneous 6 × 4.5 cm mass [Figure 2].

In conclusion, the tumor was classified as IE stage diffuse B-cell lymphoma (single, extra-nodal, without B symptoms according to the Ann Arbor classification). A rituximab-combined chemotherapy R-CHOP (cyclophosphamide, adryamicine, vincristine, and prednisolone) was prescribed, to be administrated every 3 weeks for a total of six cycles. Surgical excision of the mass was not possible. Although the patient showed good clinical response, he died of cardiac toxicity after 8 months (six cycles of chemotherapy).


Primary malignant tumors of the corpora cavernosa are extremely rare. Only one case of perineal reticulum cell sarcoma can be found in the literature,[1] and it was described as a perineal mass with priapism. Malignancies of the corpora cavernosa often appear as a primary involvement of a tumour of the shaft of the penis, frequently advanced squamous carcinoma,[4] rarely lymphomas.[2] The common presentation in those cases is a palpable nodular mass in the shaft of the penis. Both advanced bladder[5] and prostate cancer may also display an involvement of the corpora cavernosa. However, the clinical presentation in these cases is “malignant” priapism.[5]

As far as the lymphomas of the low urinary tract and genitalia are concerned, the testis is the most common site of lymphomatous involvement of the male genitalia.[4] Diffuse large B-cell lymphomas are the most frequent lymphomas of male genitalia. Classical treatment of extranodal large B-cell lymphomas is rituximab-combined chemotherapy R-CHOP,[3] and 4000–4400 rads radiation is added in selected cases. In extranodal primary affection, surgical excision should be performed in small lesions when these are reachable,[2] but radical surgery and amputations should be avoided in low urinary tract lymphomas.

In the case presented here, surgical excision was not possible. The location and extension of the tumor conditioned nonsurgical treatment. Six cycles of rituximab-combined chemotherapy R-CHOP were prescribed. Radiation therapy was envisaged, but the length of the mass invited us to reserve radiation for the residual tumor after chemotherapy. The clinical response was successful with chemotherapy alone. Perineal swelling decreased and the urinary flow increased. However, heart toxicity of chemotherapy led to the patient's death 8 months after the diagnosis.

The origin primary diffuse large B-cell lymphoma of the corpora cavernosa is uncertain. Because there is no lymphoid tissue in the corpora cavernosa, it may be initially considered as a primary lymphoma. However, it could also be a clinical manifestation of hidden nodal disease. The CT excluded thoracic or abdominal primary origin. Magnetic resonance is the best radiological exploration in those cases, because it provides optimum information about tumor stage and infiltration of neighbor organs. However, magnetic resonance cannot be performed in patients bearing a cardiac pacemaker.

The absence of priapism in this case might be due to a severe peripheral vasculopathy and the Leriche syndrome. Other primary origin of this tumor could be considered, such as the prostate, the urethra, or the rectum. Compression of bulbar urethra showed up as low urinary tract syndrome, simulating a prostatic obstruction. Prostatic and rectal diseases were excluded by digital rectal examination, ultrasonography, and PSA. Voiding cistourethrography also excluded the urethra as the origin of the lymphoma.

To our knowledge, this is the first case of lymphoma of the corpora cavernosa without penile involvement described in the medical literature. The relevance of this case resides in its exceptionality, its clinical presentation simulating a urethral stricture, the need of biopsy to provide an accurate the diagnosis, and the potential toxicity of the aggressive chemotherapy treatment used in these cases of lymphomas in aged population.


Source of Support: Nil

Conflict of Interest: None declared.

1. Weimar G,Culp DA,Loening S,Narayana A. Urogenital involvement by malignant lymphomasJ UrolYear: 198112523017009888
2. Ibarz Servio L,Arzoz Fábregas M,Ruiz Domínguez JM,Batlle Massana M,Mate Sanz JL,Saladié Roig JM. Primary lymphoma of penisActas Urol EspYear: 200933826919757671
3. Kim HY,Oh SY,Lee S,Lee DM,Kim SH,Kwon HC,et al. Eated by local excision followed by rituximab-containing chemotherapyActa HaematolYear: 2008120150219039206
4. Bañón Pérez VJ,Nicolás Torralba JA,Valdelvira Nadal P,Server Pastor G,Martínez Barba E,Gómez Gómez G,et al. Neoplasias malignas del peneActas Urol EspYear: 200024652811103503
5. Guvel S,Kilinc F,Torun D,Egilmez T,Ozkardes H. Malignant priapism secondary to bladder cancerJ AndrolYear: 20032449950012826689


[Figure ID: F1]
Figure 1 

Diffuse infiltration of large, atypical lymphoid cells (H and E stain, ×400), strongly positive for CD20 (inset, ×400)

[Figure ID: F2]
Figure 2 

Sagital TC view: The anatomy of corpora cavernosa is replaced by a heterogeneous 6 × 4.5 cm mass

Article Categories:
  • Case Report

Keywords: Corpora cavernosa, lymphoma, perineum tumor, urinary obstruction.

Previous Document:  Incomplete transverse vesical septum: An unusual congenital anomaly.
Next Document:  Hepatorenal bypass using autogenous, free internal iliac artery graft: An attractive alternative to ...