Document Detail


Primary cytomegalovirus infection and liver involvement in early infancy.
MedLine Citation:
PMID:  174245     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Virus isolation and determination of serum transaminase activity in 237 patients under one year of age were undertaken to clarify the etiologic significance of primary infection with cytomegalovirus (CMV) in infancy. The rates of virus recovery from infants with liver involvement were 37% (29/78) and 42% (28/66), as determined by serum glutamic oxaloacetic (S-GOT) and serum glutamic pyruvic (S-GPT) transaminase values. In contrast, CMV was recovered from 14% (18/127) and 13% (18/141) of infants with normal S-GOT and S-GPT values. The differences in the rates of virus recovery between both groups were more pronounced in infants under three months of age, that is, 5 to 7 times higher rates in infants with liver involvement. Correlation between complement-fixing antibody and liver involvement, however, was not significant, probably because of the influence by maternal antibody. Majority of infants infected with CMV are postulated to involve liver during immediate months after onset of virus excretion.
Authors:
S Chiba; S Hori; N Kawamura; T Nakao
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Tohoku journal of experimental medicine     Volume:  117     ISSN:  0040-8727     ISO Abbreviation:  Tohoku J. Exp. Med.     Publication Date:  1975 Oct 
Date Detail:
Created Date:  1976-03-30     Completed Date:  1976-03-30     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0417355     Medline TA:  Tohoku J Exp Med     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  143-51     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Age Factors
Alanine Transaminase / blood
Antibodies, Viral / isolation & purification
Aspartate Aminotransferases / blood
Cytomegalovirus / immunology,  isolation & purification*
Cytomegalovirus Infections / complications,  immunology,  microbiology*,  urine
Hepatitis / microbiology
Humans
Infant
Infant, Newborn
Infant, Newborn, Diseases / microbiology
Liver Diseases / complications,  immunology,  microbiology*
Saliva / microbiology
Chemical
Reg. No./Substance:
0/Antibodies, Viral; EC 2.6.1.1/Aspartate Aminotransferases; EC 2.6.1.2/Alanine Transaminase

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