Document Detail

Primary cutaneous myxoid spindle cell squamous cell carcinoma: a clinicopathologic study and review of the literature.
MedLine Citation:
PMID:  19811587     Owner:  NLM     Status:  MEDLINE    
Mucocutaneous squamous cell carcinoma (SCC) may rarely exhibit intracellular mucin production. Extracellular mucin production is an even rarer finding in SCC that is not well documented in the literature. Here, we report six cases of primary cutaneous and mucocutaneous SCC with prominent extracellular stromal mucin deposition and an epithelial spindle cell component. We propose the term 'yxoid spindle cell SCC' (MSC SCC) to describe the histologic characteristics of these six cases. We also propose a set of histologic and immunohistochemical findings for distinguishing MSC SCC from primary cutaneous and metastatic spindle cell neoplasms including other sarcomatoid carcinomas, myxoid sarcomas and the spindle cell variant of atypical fibroxanthoma (AFX). The criteria can also help discern MSC SCC from spindle cell melanomas, which may rarely show a prominent myxoid stroma. Given the small numbers of cases reported to date, the presence of prominent myxoid stroma in primary cutaneous spindle cell SCC has unknown prognostic significance at this time.
Aparche Yang; Andrew Hanley; Elsa F Velazquez; David S Cassarino
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2009-10-07
Journal Detail:
Title:  Journal of cutaneous pathology     Volume:  37     ISSN:  1600-0560     ISO Abbreviation:  J. Cutan. Pathol.     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-04-09     Completed Date:  2010-06-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0425124     Medline TA:  J Cutan Pathol     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  465-74     Citation Subset:  IM    
Department of Dermatology, Kaiser Permanente, Mission Viejo, CA, USA.
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MeSH Terms
Aged, 80 and over
Arm / pathology
Carcinoma, Squamous Cell / metabolism,  pathology*
Head and Neck Neoplasms / metabolism,  pathology*
Middle Aged
Nose / metabolism,  pathology
Penis / metabolism,  pathology
Skin Neoplasms / metabolism,  pathology*
Tumor Markers, Biological / metabolism
Reg. No./Substance:
0/Tumor Markers, Biological

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