| Primary cutaneous ganglioneuroma: a report of two cases and literature review. | |
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MedLine Citation:
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PMID: 12775986 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Primary cutaneous ganglioneuroma is a rare neoplasm first described by Collins et al. in 1972. Eight cases have been reported in the English literature to date. We report two cases of solitary cutaneous ganglioneuroma, one constituting, to our knowledge, the first reported case of this entity occurring on the face. Clinically, both lesions were firm flesh-colored papules and asymptomatic, being removed primarily for cosmesis. Neither patient had any significant past medical history. Histologically, both neoplasms consisted of relatively well-circumscribed spindle cell proliferations of axons and Schwann cells with interspersed mature ganglion cells. There was also focal myxoid change. The spindle cell component stained positively for S-100 protein, and the ganglion cells stained positively for glial fibrillary acidic protein and neurofilaments by routine immunohistochemistry. |
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Authors:
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Christopher A Wallace; James R Hallman; Omar P Sangueza |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: The American Journal of dermatopathology Volume: 25 ISSN: 0193-1091 ISO Abbreviation: Am J Dermatopathol Publication Date: 2003 Jun |
Date Detail:
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Created Date: 2003-05-30 Completed Date: 2003-10-07 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7911005 Medline TA: Am J Dermatopathol Country: United States |
Other Details:
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Languages: eng Pagination: 239-42 Citation Subset: IM |
Affiliation:
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Department of Pathology and Dermatology, Wake Forest University Baptist Medical Center, Winston-Salem, NC 27157, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Female Ganglioneuroma / chemistry, pathology*, surgery Glial Fibrillary Acidic Protein / analysis Humans Immunoenzyme Techniques Male Middle Aged Neurofilament Proteins / analysis S100 Proteins / analysis Skin Neoplasms / chemistry, pathology*, surgery Treatment Outcome Tumor Markers, Biological / analysis |
| Chemical | |
Reg. No./Substance:
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0/Glial Fibrillary Acidic Protein; 0/Neurofilament Proteins; 0/S100 Proteins; 0/Tumor Markers, Biological |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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