| Primary cutaneous angioimmunoblastic T-cell lymphoma histologically mimicking an inflammatory dermatosis. | |
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MedLine Citation:
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PMID: 20677543 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Angioimmunoblastic T-cell lymphoma (AITL) is a systemic lymphoproliferative disease characterized by a polymorphous neoplastic infiltrate involving lymph nodes as well as extranodal locations, including the skin. Cutaneous involvement is seen in approximately 50 percent of cases and is usually secondary to systemic disease. Patients with cutaneous involvement classically present with a transient morbilliform eruption of the trunk; however, papules, nodules, urticarial plaques and erythroderma have also been reported. In contrast, primary cutaneous AITL is exceedingly rare. The authors report a case of a 79-year-old woman with AITL who presented with primary cutaneous tumors and ulcerated nodules, with no evidence of systemic involvement, hypergammaglobinemia, or B symptoms. Histologically, a subtle lymphoid infiltrate was present, dominated by marked fibrosis and a diffuse infiltrate of neutrophils, eosinophils and plasma cells, mimicking an inflammatory or infectious etiology. This presentation presents a unique diagnostic challenge; careful investigation and strong clinical suspicion must be utilized in order to correctly identify AITL in this setting. |
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Authors:
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Erica S Smithberger; Dorna Rezania; Rahul N Chavan; Mary H Lien; Hernani D Cualing; Jane L Messina |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Journal of drugs in dermatology : JDD Volume: 9 ISSN: 1545-9616 ISO Abbreviation: J Drugs Dermatol Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-08-03 Completed Date: 2010-08-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101160020 Medline TA: J Drugs Dermatol Country: United States |
Other Details:
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Languages: eng Pagination: 851-5 Citation Subset: IM |
Affiliation:
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Department of Dermatology, University of South Florida,Tampa, FL 33612, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Dermatitis / diagnosis, pathology* Diagnosis, Differential Female Humans Immunoblastic Lymphadenopathy / diagnosis, pathology* Lymphoma, T-Cell, Cutaneous / diagnosis, pathology* Skin Neoplasms / diagnosis, pathology* |
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