Document Detail


Primary cutaneous CD30-positive anaplastic large cell lymphoma analysis.
MedLine Citation:
PMID:  12622927     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To examine 10 cases with primary cutaneous CD30-positive anaplastic large cell lymphoma (ALCL), analyze their clinical manifestations and pathological and immunohistochemical features, and improve early diagnosis of this disease. METHODS: We studied the morphological characteristics of primary cutaneous CD30-positive ALCL using histopathological methods. Leukocyte common antigen (LCA), CD20, CD30, CD45RO, CD68, epithelial membrane antigen (EMA), cytokeratin (CK) and HMB45 antibodies were used to determine the expression of their respective antigens from routine paraffin samples of the patients. RESULTS: Ten patients (7 men and 3 women, aged 31 to 84 years) complained of subcutaneous masses or papular eruptions over their lower trunks and extremities. Histopathologically, the lesions were composed of numerous large round or oval pleomorphic cells. The cytoplasm was usually abundant, amphophilic or basophilic, and finely vacuolated. Nuclei were commonly eccentrically localized and lobated or horseshoed in shape, and multinucleated giant cells and Reed-Sternberg-like cells were seen. Nucleoli were generally multiple and large. Of the 10 patients, tumor cells displayed positive antigen expression of CD30 in all cases, positive CD45RO in 6 cases, positive CD20 in only 1 case, but negative CD45RO and CD20 expressions in 3 cases. Two patients died at 7 weeks and 3.4 years of follow-up, respectively. CONCLUSION: Our study highlights the importance of histopathologic features and positive CD30 staining for differentiation of this disease from other malignant skin tumors.
Authors:
Qunli Shi; Xiaojun Zhou; Xiaowen Yan; Xinyu Xu; Honglin Yin; Tong Zhong; Mikihiro Shamoto; Bin Qian
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Chinese medical journal     Volume:  115     ISSN:  0366-6999     ISO Abbreviation:  Chin. Med. J.     Publication Date:  2002 Dec 
Date Detail:
Created Date:  2003-03-07     Completed Date:  2003-03-31     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7513795     Medline TA:  Chin Med J (Engl)     Country:  China    
Other Details:
Languages:  eng     Pagination:  1802-5     Citation Subset:  IM    
Affiliation:
Department of Pathology, Nanjing General Hospital of PLA, School of Clinical Medicine, Nanjing University, Nanjing 210002, China. shiqunli203@sohu.com
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Antigens, CD30 / analysis
Antigens, CD45 / analysis
Diagnosis, Differential
Female
Humans
Immunohistochemistry
Lymphoma, Large-Cell, Anaplastic / diagnosis,  immunology,  pathology*
Male
Middle Aged
Skin Neoplasms / diagnosis,  immunology,  pathology*
Chemical
Reg. No./Substance:
0/Antigens, CD30; EC 3.1.3.48/Antigens, CD45

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