Document Detail

Primary cutaneous CD30+ large T-cell lymphoma in a patient with psoriasis treated with cyclosporine.
MedLine Citation:
PMID:  12771475     Owner:  NLM     Status:  MEDLINE    
We report the case of a 61-year-old woman who developed an anaplastic CD30+ cutaneous T-cell lymphoma during oral cyclosporine (CsA) therapy for recalcitrant psoriasis. Two months after CsA discontinuation, clinical and histological resolution of the lymphoma was observed. However, 3 years later extracutaneous involvement of the lymphoma could be detected. The association between CsA administration and the occurrence of the lymphoma may be casual, but a relationship with immunosuppression may also be hypothesized. We have reviewed all relevant data in the literature. To our knowledge, this is the first case of primary cutaneous CD30+ anaplastic large T-cell lymphoma in a patient treated with CsA for psoriasis.
M Corazza; M R Zampino; A Montanari; E Altieri; A Virgili
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Dermatology (Basel, Switzerland)     Volume:  206     ISSN:  1018-8665     ISO Abbreviation:  Dermatology (Basel)     Publication Date:  2003  
Date Detail:
Created Date:  2003-05-28     Completed Date:  2003-10-15     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9203244     Medline TA:  Dermatology     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  330-3     Citation Subset:  IM    
Copyright Information:
Copyright 2003 S. Karger AG, Basel
Dipartimento di Medicina Clinica e Sperimentale, Sezione di Dermatologia, Università di Ferrara, Italy.
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MeSH Terms
Antigens, CD30 / blood*
Cyclosporine / adverse effects*,  therapeutic use
Etretinate / therapeutic use
Fatal Outcome
Immunosuppressive Agents / adverse effects*,  therapeutic use
Keratolytic Agents / therapeutic use
Lymphoma, T-Cell, Cutaneous / chemically induced*,  immunology,  pathology
Middle Aged
Psoriasis / drug therapy*
Risk Factors
Skin Neoplasms / chemically induced*,  immunology,  pathology
Tumor Markers, Biological / blood*
Reg. No./Substance:
0/Antigens, CD30; 0/Immunosuppressive Agents; 0/Keratolytic Agents; 0/Tumor Markers, Biological; 54350-48-0/Etretinate; 59865-13-3/Cyclosporine

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