| Primary ciliary dyskinesia causing neonatal respiratory distress | |
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MedLine Citation:
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PMID: 20013568 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Primary ciliary dyskinesia (PCD) is a hereditary disorder of structure and function of the cilia of respiratory epithelium of the upper and lower airways. Prevalence is estimated with 1:15 000 to 1:30 000 births. We present a newborn infant with respiratory distress caused by PCD. PATIENT: On the first day of life, the male newborn developed dyspnoe and cyanosis, so that CPAP and short term ventilation was necessary. Varying atelectasis impressed on the chest radiographs and the diagnosis of PCD was made by nasal brush biopsies. Causative is a lack of the inner dynein arms of the cilia. The clinical features of newborns with the diagnoses of PCD are listed and compared with the own case. CONCLUSION: PCD is a rare cause of neonatal respiratory distress and should be considered in term infants with unknown and prolonged course even if Situs inversus is lacking. |
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Authors:
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C H?nseler; L Lange; A Kribs; A Vierzig; B Roth |
Publication Detail:
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Type: English Abstract; Journal Article |
Journal Detail:
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Title: Klinische P?diatrie Volume: 221 ISSN: 1439-3824 ISO Abbreviation: Klin Padiatr Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2009-12-16 Completed Date: 2010-03-15 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0326144 Medline TA: Klin Padiatr Country: Germany |
Other Details:
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Languages: ger Pagination: 440-3 Citation Subset: IM |
Copyright Information:
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(c) Georg Thieme Verlag KG Stuttgart New York. |
Affiliation:
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Bereich Neonatologie, Kinderklinik der Universit?t zu K?ln. christoph.huenseler@uni-koeln.de |
Vernacular Title:
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Prim?re Ziliendyskinesie als Ursache neonataler Atemnot. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Inhalation Albuterol / administration & dosage Axonemal Dyneins / deficiency, genetics Biopsy Bronchoscopy Combined Modality Therapy Continuous Positive Airway Pressure Diagnosis, Differential Humans Infant, Newborn Kartagener Syndrome / diagnosis, genetics*, pathology, therapy Male Oxygen Inhalation Therapy Physical Therapy Modalities Positive-Pressure Respiration Pulmonary Atelectasis / etiology Respiratory Distress Syndrome, Newborn / diagnosis, genetics*, pathology, therapy |
| Chemical | |
Reg. No./Substance:
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18559-94-9/Albuterol; EC 3.6.4.2/Axonemal Dyneins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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