| Primary cilia and the cell cycle. | |
| | |
MedLine Citation:
|
PMID: 20362089 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Cilia are microtubule-based structures that protrude from the cell surface and function as sensors for mechanical and chemical environmental cues that regulate cellular differentiation or division. In metazoans, ciliary signaling is important during organismal development and in the homeostasis controls of adult tissues, with receptors for the Hedgehog, platelet derived growth factor (PDGF), Wnt, and other signaling cascades arrayed and active along the ciliary membrane. In normal cells, cilia are dynamically regulated during cell cycle progression: present in G0 and G1 cells, and usually in S/G2 cells, but almost invariably resorbed before mitotic entry, to reappear post-cytokinesis. This periodic resorption and reassembly of cilia, specified by the intrinsic cell cycle the intrinsic cell cycle machinery, influences the susceptibility of cells to the influence of extrinsic signals with cilia-associated receptors. Pathogenic conditions of mammals associated with loss of or defects in ciliary integrity include a number of developmental disorders, cystic syndromes in adults, and some cancers. With the continuing expansion of the list of human diseases associated with ciliary abnormalities, the identification of the cellular mechanisms regulating ciliary growth and disassembly has become a topic of intense research interest. Although these mechanisms are far from being understood, a number of recent studies have begun to identify key regulatory factors that may begin to offer insight into disease pathogenesis and treatment. In this chapter we will discuss the current state of knowledge regarding cell cycle control of ciliary dynamics, and provide general methods that can be applied to investigate cell cycle-dependent ciliary growth and disassembly. |
| | |
Authors:
|
Olga V Plotnikova; Elena N Pugacheva; Erica A Golemis |
Related Documents
:
|
22538089 - Il-10-producing regulatory b10 cells ameliorate collagen-induced arthritis via suppress... 7547499 - The nonstructural proteins of the autonomous parvovirus minute virus of mice interfere ... 17466069 - The lin-35/rb and rnai pathways cooperate to regulate a key cell cycle transition in c.... 17302939 - Involvement of rho-type gtpase in control of cell size in saccharomyces cerevisiae. 3260989 - The synthetic immunomodulator muramyl dipeptide (mdp) can stimulate activated b cells. 11731319 - Cell cycle control of cell morphogenesis in caulobacter. 6512879 - Squamous cell carcinoma of the urethra. 16917009 - Hbz, a new important player in the mystery of adult t-cell leukemia. 3281899 - Variation in the expression of cell wall proteins of staphylococcus aureus grown on sol... |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. Date: 2009-12-23 |
Journal Detail:
|
Title: Methods in cell biology Volume: 94 ISSN: 0091-679X ISO Abbreviation: Methods Cell Biol. Publication Date: 2009 |
Date Detail:
|
Created Date: 2010-04-05 Completed Date: 2010-06-21 Revised Date: 2010-12-03 |
Medline Journal Info:
|
Nlm Unique ID: 0373334 Medline TA: Methods Cell Biol Country: United States |
Other Details:
|
Languages: eng Pagination: 137-60 Citation Subset: IM |
Copyright Information:
|
2009 Elsevier Inc. All rights reserved. |
Affiliation:
|
Program in Molecular and Translational Medicine, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Cell Cycle / physiology* Cell Cycle Proteins / metabolism Cell Fractionation / methods Cells, Cultured Cilia* / metabolism, ultrastructure Glycogen Synthase Kinase 3 / metabolism Humans Signal Transduction / physiology Von Hippel-Lindau Tumor Suppressor Protein / metabolism |
| Grant Support | |
ID/Acronym/Agency:
|
CA-06927/CA/NCI NIH HHS; P30 CA006927-38/CA/NCI NIH HHS; R01 CA-113342/CA/NCI NIH HHS; R01 CA-63366/CA/NCI NIH HHS; R01 CA063366-09/CA/NCI NIH HHS; R01 CA113342-03/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Cell Cycle Proteins; EC 2.7.11.26/Glycogen Synthase Kinase 3; EC 6.3.2.19/Von Hippel-Lindau Tumor Suppressor Protein |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Analyzing primary cilia by multiphoton microscopy.
Next Document: Utilization of conditional alleles to study the role of the primary cilium in obesity.