Document Detail

Primary chiasmal germinoma. A case report and review of the literature.
MedLine Citation:
PMID:  2139058     Owner:  NLM     Status:  MEDLINE    
A case is presented in which an adult man with painless progressive loss of vision subsequently was found to have a primary suprasellar/perichiasmal germinoma (ectopic pinealoma). A review of the literature revealed 93 similar cases of germinoma occurring in the perichiasmal region and these are tabulated. The diagnosis and management of this lesion are discussed, including the recognition of the characteristic neuroendocrinologic triad of diabetes insipidus, visual changes, and hypopituitarism. Of 64 cases from the literature wherein presenting symptoms were reported, 56 (87.5%) had diabetes insipidus, 53 (82.8%) visual changes, and 36 (56%) hypopituitarism. A review of the literature suggests that diabetes insipidus is usually the initial symptom in suprasellar germinoma. However, we wish to emphasize the ophthalmologic presentation of this entity, because of ophthalmologic presentation of this entity, because patients in the age group most affected (adolescents) will often not recognize symptoms of diabetes insipidus, but will first seek medical attention for painless progressive loss of vision suggestive of chiasmal compression. The radiosensitivity of this lesion is also discussed. Of 61 patients receiving irradiation therapy, 42 (68%) were surviving at the time of their individual case report. No patient in the review survived without irradiation therapy.
C B Bowman; B K Farris
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Journal of clinical neuro-ophthalmology     Volume:  10     ISSN:  0272-846X     ISO Abbreviation:  J Clin Neuroophthalmol     Publication Date:  1990 Mar 
Date Detail:
Created Date:  1990-05-24     Completed Date:  1990-05-24     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8109051     Medline TA:  J Clin Neuroophthalmol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  9-17     Citation Subset:  IM    
University of Oklahoma College of Medicine, Dean A. McGee Eye Institute, Oklahoma City 73104.
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MeSH Terms
Cranial Nerve Neoplasms / complications,  diagnosis*,  therapy
Diabetes Insipidus / complications
Dysgerminoma / complications,  diagnosis*,  therapy
Hypopituitarism / complications
Magnetic Resonance Imaging
Optic Chiasm*
Testosterone / blood
Tomography, X-Ray Computed
Visual Acuity
Reg. No./Substance:

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