| Primary cerebral toxoplasmosis: a rare case of ventriculitis and hydrocephalus in AIDS. | |
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MedLine Citation:
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PMID: 15943161 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We describe the clinical, radiological and neuropathological findings in an adult AIDS patient presenting with ventriculitis and hydrocephalus as the primary manifestations of cerebral toxoplasmosis. Clinical symptoms including fever, headache, changes in mental status and focal neurological deficits were non-specific. Cranial computed tomography showed a subtile ventricular dilatation whereas magnetic resonance imaging disclosed triventricular hydrocephalus due to stenosis of the aqueduct and a periventricular nodular rim of high signal intensity on T2- and proton density-weighted images. This rim also showed a slight enhancement on post-contrast T1-weighted images. Focal intracerebral lesions could not be delineated, neither by neuroimaging nor by pathology. Neuropathological examination showed severe ventriculitis with large ependymal and subependymal necrosis as well as dilatation of the lateral and the third ventricle. The only microorganism demonstrated at histology in the central nervous system was Toxoplasma gondii. We conclude that ventriculitis and hydrocephalus without any focal parenchymal lesion may be the only manifestations of CNS toxoplasmosis. It is important to recognize this unusual form of presentation of cerebral toxoplasmosis in order to perform specific therapy. |
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Authors:
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M Sell; R Klingebiel; G Di Iorio; S Sampaolo |
Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Clinical neuropathology Volume: 24 ISSN: 0722-5091 ISO Abbreviation: Clin. Neuropathol. Publication Date: 2005 May-Jun |
Date Detail:
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Created Date: 2005-06-09 Completed Date: 2005-08-18 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8214420 Medline TA: Clin Neuropathol Country: Germany |
Other Details:
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Languages: eng Pagination: 106-11 Citation Subset: IM |
Affiliation:
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Institute of Pathology, Vivantes Klinikum Neukölln, Charité Campus Mitte, Universitary Medicine, Berlin, Germany. manfredsell@web.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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AIDS-Related Opportunistic Infections
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complications,
parasitology,
pathology* Animals Anti-Bacterial Agents / therapeutic use Brain / parasitology, pathology*, surgery Cerebral Ventricles / parasitology, pathology*, surgery Cerebrospinal Fluid Shunts Encephalitis / parasitology, pathology*, therapy Fatal Outcome Humans Hydrocephalus / parasitology, pathology*, surgery Magnetic Resonance Imaging Male Middle Aged Steroids / therapeutic use Syphilis / complications Tomography, X-Ray Computed Toxoplasmosis, Cerebral / complications, parasitology, pathology* |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; 0/Steroids |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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