| Primary central nervous system vasculitis presenting with intracranial hemorrhage. | |
| | |
MedLine Citation:
|
PMID: 22038406 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
OBJECTIVE: To describe a subset of cases in a large retrospectively identified cohort of patients with primary central nervous system vasculitis (PCNSV) who present with intracranial hemorrhage. METHODS: The study consisted of a cohort of 131 consecutive patients with PCNSV who were seen at the Mayo Clinic over a 25-year period from 1983 to 2007. The diagnosis of PCNSV was based on findings of brain or spinal cord biopsy, cerebral angiography, or both. Intracranial hemorrhage at presentation was defined as the presence of intracerebral or subarachnoid hemorrhage on computed tomography or magnetic resonance imaging (MRI) of the brain within 3 months of the date of PCNSV diagnosis. The clinical, laboratory, radiologic, and pathologic findings, therapy, and outcomes in patients presenting with intracranial hemorrhage were compared with those without intracranial hemorrhage. RESULTS: Sixteen patients (12.2%) had evidence of intracranial hemorrhage at or near the time of diagnosis. Twelve patients had intracerebral hemorrhage, and 4 had subarachnoid hemorrhage. Twelve patients were diagnosed by findings on angiography and 4 by findings on CNS biopsy. Compared with the 115 patients without intracranial hemorrhage, the 16 patients presenting with intracranial hemorrhage were more frequently women, less frequently had altered cognition, a persistent neurologic deficit, or stroke at presentation, less frequently had MRI evidence of cerebral infarctions, and less frequently needed therapy at last followup. A necrotizing histopathologic pattern of vasculitis was observed in 3 of the 4 patients with positive biopsy findings (75%). CONCLUSION: Our findings suggest that intracranial hemorrhage may not be an infrequent occurrence in early PCNSV. Necrotizing vasculitis may be a predominant histopathologic pattern. |
| | |
Authors:
|
Carlo Salvarani; Robert D Brown; Kenneth T Calamia; Teresa J H Christianson; John Huston; James F Meschia; Caterina Giannini; Dylan V Miller; Gene G Hunder |
Related Documents
:
|
19653086 - Fibrates may cause an abnormal urinary betaine loss which is associated with elevations... 942606 - Biliary excretion of digoxin in man. 6782876 - The pathogenesis of hyperchloremic metabolic acidosis associated with kidney transplant... 1509636 - Immunoreactive low-molecular-weight epidermal growth factor in urine of patients with r... 1285376 - Kabuki make-up (niikawa-kuroki) syndrome: a study of 16 non-japanese cases. 21627646 - Aphasic status epilepticus: electroclinical correlation. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Arthritis and rheumatism Volume: 63 ISSN: 1529-0131 ISO Abbreviation: Arthritis Rheum. Publication Date: 2011 Nov |
Date Detail:
|
Created Date: 2011-10-31 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0370605 Medline TA: Arthritis Rheum Country: United States |
Other Details:
|
Languages: eng Pagination: 3598-606 Citation Subset: AIM; IM |
Copyright Information:
|
Copyright © 2011 by the American College of Rheumatology. |
Affiliation:
|
Mayo Clinic, Rochester, Minnesota. salvarani.carlo@asmn.re.it. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Copy number variations of interleukin-17F, interleukin-21, and interleukin-22 are associated with sy...
Next Document: Sexual, Behavioral, and Quality of Life Characteristics of Healthy Weight, Overweight, and Obese Gay...