| Primary central nervous system lymphoma of the brain stem responding favorably to radiosurgery: a case report and literature review. | |
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MedLine Citation:
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PMID: 16253683 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To explore various therapeutic alternatives and evaluate the clinical results of patients with primary central nervous system lymphoma (PCNSL). We report a case of PCNSL with involvement of the brain stem managed with radiosurgery using the Leksell gamma knife as the treatment modality. CASE DESCRIPTION: A 55-year-old white woman presented with complaints of weakness on the left side of her body and double vision associated with a frontal headache. Nervous system examination revealed right-sided oculomotor palsy and left-sided motor paresis, grade 2/5, in both upper and lower limbs. Her Karnofsky performance score was 50. A contrast-enhanced magnetic resonance imaging scan of the brain revealed an irregular space-occupying lesion in the pons that enhanced uniformly with gadolinium. A frame-based stereotactic biopsy was performed revealing a B-cell malignant lymphoma. Subsequently, stereotactic radiosurgery using the Leksell gamma knife was performed. A dose of 11 Gy was delivered to the tumor margin. A follow-up magnetic resonance imaging scan after 2 months revealed a 50% reduction in the size of the enhancing lesion. CONCLUSION: Our own results and limited evidence from the literature suggest stereotactic radiosurgery as a potentially safe and effective treatment option in patients with PCNSL. |
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Authors:
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Peter G Campbell; Ajay Jawahar; Marjorie R Fowler; Allyson Delaune; Anil Nanda |
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Publication Detail:
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Type: Case Reports; Journal Article; Review |
Journal Detail:
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Title: Surgical neurology Volume: 64 ISSN: 0090-3019 ISO Abbreviation: Surg Neurol Publication Date: 2005 Nov |
Date Detail:
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Created Date: 2005-10-28 Completed Date: 2005-12-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0367070 Medline TA: Surg Neurol Country: United States |
Other Details:
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Languages: eng Pagination: 400-5; discussion 405 Citation Subset: IM |
Affiliation:
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Department of Neurosurgery, Louisiana State University Health Sciences Center in Shreveport, Shreveport, LA 71130-3932, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Brain Stem Neoplasms
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pathology,
surgery* Female Health Status Humans Lymphoma, B-Cell / pathology, surgery* Magnetic Resonance Imaging Middle Aged Radiosurgery / methods* Treatment Outcome |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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