Document Detail


Primary central nervous system histiocytic sarcoma presenting as a postradiation sarcoma: case report and literature review.
MedLine Citation:
PMID:  23356953     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Histiocytic sarcoma (HS) is a rare neoplasm that occurs most commonly in the intestinal tract, skin, soft tissue, and lymph node. The incidence of primary central nervous system (CNS) HS is even rarer, with a total of 6 cases reported in the literature. An etiologic link has not been identified for CNS HS, and the current case of primary CNS HS is unique in that an etiologic link to prior radiation therapy is identified, associated with complex cytogenetic abnormalities in the tumor. Although radiation-associated sarcomas can present as any number of different pathologic entities, this is the first reported case of a radiation-associated CNS HS. The pathologic and immunophenotypic characteristics of this case, with a nearly obscuring heavy inflammatory infiltrate and expression of monocytic/histiocytic markers (CD163, CD68, CD4, fascin), are characteristic of CNS HS. A discussion of the differential diagnosis and review of relevant literature are presented.
Authors:
Winnie Wu; Asli Tanrivermis Sayit; Harry V Vinters; Whitney Pope; Leili Mirsadraei; Jonathan Said
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Publication Detail:
Type:  Case Reports; Journal Article; Review     Date:  2013-01-26
Journal Detail:
Title:  Human pathology     Volume:  44     ISSN:  1532-8392     ISO Abbreviation:  Hum. Pathol.     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-05-20     Completed Date:  2013-07-18     Revised Date:  2014-05-20    
Medline Journal Info:
Nlm Unique ID:  9421547     Medline TA:  Hum Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1177-83     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Diagnosis, Differential
Hemangioma, Cavernous, Central Nervous System / radiotherapy,  surgery
Histiocytic Sarcoma / diagnosis*
Humans
Immunohistochemistry
Male
Middle Aged
Neoplasms, Radiation-Induced / diagnosis*
Neoplasms, Second Primary / diagnosis*
Pinealoma / radiotherapy,  surgery
Tumor Markers, Biological / analysis
Grant Support
ID/Acronym/Agency:
P50 CA092131/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Tumor Markers, Biological

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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