Document Detail


Primary cardiac diffuse large B-cell lymphoma with activated B-cell-like phenotype.
MedLine Citation:
PMID:  21934230     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Primary cardiac lymphoma (PCL) is a rare and fatal disorder. It may often mimic other common cardiac tumors like cardiac myxoma because of similarities in the clinical presentation. We report a case of PCL of diffuse large B-cell type, in a 38-year-old, immunocompetent male who presented with superior vena cava syndrome that was excised as a myxoma. Histology revealed a large cell population diffusely and strongly expressing CD45, CD20, MUM1/IRF4 and FOXP1 hinting at an activated B-cell (ABC)-like phenotype. After four cycles of Rituximab with CHOP (cyclophosphamide, hydroxydaunorubicin, Oncovin, and prednisolone) the tumor regressed completely but the patient had a relapse and subsequently succumbed to the disease confirming the aggressive nature. The aggressive behavior of PCL may be possibly linked to its ABC-like origin.
Authors:
Vijaya Gadage; Seema Kembhavi; Prabhash Kumar; Tanuja Shet
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Indian journal of pathology & microbiology     Volume:  54     ISSN:  0974-5130     ISO Abbreviation:  Indian J Pathol Microbiol     Publication Date:    2011 Jul-Sep
Date Detail:
Created Date:  2011-09-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7605904     Medline TA:  Indian J Pathol Microbiol     Country:  India    
Other Details:
Languages:  eng     Pagination:  591-3     Citation Subset:  IM    
Affiliation:
Department of Pathology, Tata Memorial Hospital, Mumbai, India.
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