| Primary cardiac diffuse large B-cell lymphoma with activated B-cell-like phenotype. | |
| | |
MedLine Citation:
|
PMID: 21934230 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Primary cardiac lymphoma (PCL) is a rare and fatal disorder. It may often mimic other common cardiac tumors like cardiac myxoma because of similarities in the clinical presentation. We report a case of PCL of diffuse large B-cell type, in a 38-year-old, immunocompetent male who presented with superior vena cava syndrome that was excised as a myxoma. Histology revealed a large cell population diffusely and strongly expressing CD45, CD20, MUM1/IRF4 and FOXP1 hinting at an activated B-cell (ABC)-like phenotype. After four cycles of Rituximab with CHOP (cyclophosphamide, hydroxydaunorubicin, Oncovin, and prednisolone) the tumor regressed completely but the patient had a relapse and subsequently succumbed to the disease confirming the aggressive nature. The aggressive behavior of PCL may be possibly linked to its ABC-like origin. |
| | |
Authors:
|
Vijaya Gadage; Seema Kembhavi; Prabhash Kumar; Tanuja Shet |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Indian journal of pathology & microbiology Volume: 54 ISSN: 0974-5130 ISO Abbreviation: Indian J Pathol Microbiol Publication Date: 2011 Jul-Sep |
Date Detail:
|
Created Date: 2011-09-21 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7605904 Medline TA: Indian J Pathol Microbiol Country: India |
Other Details:
|
Languages: eng Pagination: 591-3 Citation Subset: IM |
Affiliation:
|
Department of Pathology, Tata Memorial Hospital, Mumbai, India. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Primary lymphoma of the spermatic cord: A case report and review of the literature.
Next Document: Hemophagocytic syndrome associated with Plasmodium falciparum infection.