Document Detail

Primary "breast-like" cancer of the vulva: a case report and critical review of the literature.
MedLine Citation:
PMID:  16515638     Owner:  NLM     Status:  MEDLINE    
Ectopic mammary gland tissue in the vulva is an uncommon clinical or pathologic finding. Such ectopic tissue can be the site of the same physiologic and pathologic processes found in the normal breast. However, the occurrence of adenocarcinoma is very rare, the first case being reported by Greene in 1935. We here report the 16th case of primary "breast-like" cancer arising in the vulva, together with a critical review of the literature, in order to highlight the dilemmas of a clinical approach to this neoplasm. Clear guidelines for diagnosis and therapy are still unavailable. The main diagnostic criteria suggested by the authors of previous reports are discussed together with our own findings. The therapeutic approach to this rare malignancy is also critically reviewed. In our opinion, when diagnosis of breast-like vulvar cancer is finally confirmed, treatment and follow-up should be the same as that would be chosen in a case of orthotopic breast neoplasm.
S Fracchioli; M Puopolo; I A Rigault De La Longrais; M Scozzafava; F Bogliatto; R Arisio; L Micheletti; D Katsaros
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  International journal of gynecological cancer : official journal of the International Gynecological Cancer Society     Volume:  16 Suppl 1     ISSN:  1048-891X     ISO Abbreviation:  Int. J. Gynecol. Cancer     Publication Date:    2006 Jan-Feb
Date Detail:
Created Date:  2006-03-06     Completed Date:  2006-07-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9111626     Medline TA:  Int J Gynecol Cancer     Country:  United States    
Other Details:
Languages:  eng     Pagination:  423-8     Citation Subset:  IM    
Gynecologic Oncology Unit, S. Anna Hospital, Turin, Italy.
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MeSH Terms
Antineoplastic Combined Chemotherapy Protocols / administration & dosage
Carcinoma, Ductal, Breast / pathology*,  therapy
Cyclophosphamide / administration & dosage
Doxorubicin / administration & dosage
Fluorouracil / administration & dosage
Gynecologic Surgical Procedures
Middle Aged
Vulvar Neoplasms / pathology*,  therapy
Reg. No./Substance:
0/CAF protocol; 23214-92-8/Doxorubicin; 50-18-0/Cyclophosphamide; 51-21-8/Fluorouracil

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