Primary bone marrow B-cell lymphoma: report of four cases. | |
MedLine Citation:
|
PMID: 12634906 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Bone marrow involvement is infrequent at presentation in cases of diffuse large B-cell lymphoma. We report four adult patients with diffuse large B-cell lymphoma in whom bone marrow involvement with hematologic manifestations was the predominant clinical feature at presentation. Three patients presented with a leukoerythroblastic blood picture and one with pancytopenia. In each case, the unusual hematologic manifestations, with bone marrow replacement and the presence of immature forms in the peripheral blood, led to consideration of alternative hematologic diagnoses, including acute granulocytic leukemia in three cases and a myelodysplastic syndrome in one. The correct diagnoses were established by immunohistochemistry on formalin-fixed, paraffin-embedded bone marrow for two cases and by flow cytometry on aspirated bone marrow or peripheral blood lymphocytes for the other two. Diffuse large B-cell lymphoma should be considered in the differential diagnosis of unusual hematologic presentations, particularly in the elderly. |
Authors:
|
James A Strauchen |
Related Documents
:
|
2258466 - Pathological and immunohistochemical studies of follicular lymphoma in two calves. 9580256 - Angiocentric cutaneous t-cell lymphoma of childhood (hydroa-like lymphoma): a distincti... 19097386 - Bacillus circulans paracardiac infection in non-hodgkin lymphoma--a case report. 1332376 - Primary vulvar lymphoma presenting as a clitoral tumor. 1936006 - Intra-hisian 2:1 atrioventricular block secondary to lyme disease. 8470446 - Splenic aneurysm rupture. case report and review of the literature. |
Publication Detail:
|
Type: Case Reports; Journal Article |
Journal Detail:
|
Title: The Mount Sinai journal of medicine, New York Volume: 70 ISSN: 0027-2507 ISO Abbreviation: Mt. Sinai J. Med. Publication Date: 2003 Mar |
Date Detail:
|
Created Date: 2003-03-13 Completed Date: 2003-06-17 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 0241032 Medline TA: Mt Sinai J Med Country: United States |
Other Details:
|
Languages: eng Pagination: 133-8 Citation Subset: IM |
Affiliation:
|
Department of Pathology, Mount Sinai School of Medicine, New York, NY 10029, USA. james.strauchen@mssm.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
MeSH Terms | |
Descriptor/Qualifier:
|
Aged Aged, 80 and over Bone Marrow Neoplasms / chemistry, diagnosis*, pathology Female Humans Immunohistochemistry Lymphoma, B-Cell / chemistry, diagnosis*, pathology Male Middle Aged |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Small bowel perforation secondary to metastatic lung cancer: a case report and review of the literat...
Next Document: New cytotoxic agents and molecular-targeted therapies in the treatment of metastatic breast cancer.