| Primary bone marrow B-cell lymphoma: report of four cases. | |
MedLine Citation:
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PMID: 12634906 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Bone marrow involvement is infrequent at presentation in cases of diffuse large B-cell lymphoma. We report four adult patients with diffuse large B-cell lymphoma in whom bone marrow involvement with hematologic manifestations was the predominant clinical feature at presentation. Three patients presented with a leukoerythroblastic blood picture and one with pancytopenia. In each case, the unusual hematologic manifestations, with bone marrow replacement and the presence of immature forms in the peripheral blood, led to consideration of alternative hematologic diagnoses, including acute granulocytic leukemia in three cases and a myelodysplastic syndrome in one. The correct diagnoses were established by immunohistochemistry on formalin-fixed, paraffin-embedded bone marrow for two cases and by flow cytometry on aspirated bone marrow or peripheral blood lymphocytes for the other two. Diffuse large B-cell lymphoma should be considered in the differential diagnosis of unusual hematologic presentations, particularly in the elderly. |
Authors:
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James A Strauchen |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: The Mount Sinai journal of medicine, New York Volume: 70 ISSN: 0027-2507 ISO Abbreviation: Mt. Sinai J. Med. Publication Date: 2003 Mar |
Date Detail:
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Created Date: 2003-03-13 Completed Date: 2003-06-17 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0241032 Medline TA: Mt Sinai J Med Country: United States |
Other Details:
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Languages: eng Pagination: 133-8 Citation Subset: IM |
Affiliation:
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Department of Pathology, Mount Sinai School of Medicine, New York, NY 10029, USA. james.strauchen@mssm.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Bone Marrow Neoplasms / chemistry, diagnosis*, pathology Female Humans Immunohistochemistry Lymphoma, B-Cell / chemistry, diagnosis*, pathology Male Middle Aged |
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