Document Detail

Primary bone marrow B-cell lymphoma: report of four cases.
MedLine Citation:
PMID:  12634906     Owner:  NLM     Status:  MEDLINE    
Bone marrow involvement is infrequent at presentation in cases of diffuse large B-cell lymphoma. We report four adult patients with diffuse large B-cell lymphoma in whom bone marrow involvement with hematologic manifestations was the predominant clinical feature at presentation. Three patients presented with a leukoerythroblastic blood picture and one with pancytopenia. In each case, the unusual hematologic manifestations, with bone marrow replacement and the presence of immature forms in the peripheral blood, led to consideration of alternative hematologic diagnoses, including acute granulocytic leukemia in three cases and a myelodysplastic syndrome in one. The correct diagnoses were established by immunohistochemistry on formalin-fixed, paraffin-embedded bone marrow for two cases and by flow cytometry on aspirated bone marrow or peripheral blood lymphocytes for the other two. Diffuse large B-cell lymphoma should be considered in the differential diagnosis of unusual hematologic presentations, particularly in the elderly.
James A Strauchen
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The Mount Sinai journal of medicine, New York     Volume:  70     ISSN:  0027-2507     ISO Abbreviation:  Mt. Sinai J. Med.     Publication Date:  2003 Mar 
Date Detail:
Created Date:  2003-03-13     Completed Date:  2003-06-17     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0241032     Medline TA:  Mt Sinai J Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  133-8     Citation Subset:  IM    
Department of Pathology, Mount Sinai School of Medicine, New York, NY 10029, USA.
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MeSH Terms
Aged, 80 and over
Bone Marrow Neoplasms / chemistry,  diagnosis*,  pathology
Lymphoma, B-Cell / chemistry,  diagnosis*,  pathology
Middle Aged

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