Document Detail


Primary biliary cirrhosis: therapeutic advances.
MedLine Citation:
PMID:  23540499     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Primary biliary cirrhosis (PBC) is a chronic and slowly progressive cholestatic liver disease characterized by destruction of the interlobular bile ducts, which, if untreated, leads to fibrosis, biliary cirrhosis, and liver failure. Because liver transplantation remains the only curative option for PBC, the goals of treatment are to slow the rate of progression, to alleviate related symptoms, and to prevent complications. Ursodeoxycholic acid is the only US Food and Drug Administration-approved medical treatment of PBC. Several agents are undergoing evaluation as monotherapy or as an adjuvant to ursodeoxycholic acid. This review summarizes current therapeutic advances in the care of patients with PBC.
Authors:
Frank Czul; Adam Peyton; Cynthia Levy
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinics in liver disease     Volume:  17     ISSN:  1557-8224     ISO Abbreviation:  Clin Liver Dis     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-04-01     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9710002     Medline TA:  Clin Liver Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  229-42     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 Elsevier Inc. All rights reserved.
Affiliation:
Department of Medicine, University of Miami Miller School of Medicine, Room 600D, Central Building, 1611 NW 12th Avenue, Miami, FL 33101, USA.
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