Document Detail

Primary biliary cirrhosis: survival of a large cohort of symptomatic and asymptomatic patients followed for 24 years.
MedLine Citation:
PMID:  7930469     Owner:  NLM     Status:  MEDLINE    
We extended by 10 years, a follow-up study of 279 patients with primary biliary cirrhosis initially evaluated at the Yale Liver Study Unit between 1955 and 1979. Thirty-six patients (13%) were asymptomatic at the time of diagnosis. Accurate follow-up survival data were available for 247 patients (89%), ranging up to 24 years after the original diagnosis. Median predicted survival of patients in this study from the time of diagnosis is twice as long for patients who present without symptoms compared to symptomatic patients (16 vs 7.5 years, p < 0.0001). However, overall survival of those asymptomatic patients is shorter than that predicted for an age- and gender-matched control population (p < 0.0001), a difference that became apparent only after 11 years of follow up. With a median follow up of 12.1 years, 33% of the asymptomatic patients remained free of symptoms of liver disease, However, once symptoms develop, their survival is similar to those presenting with symptoms. Independent predictors of diminished survival include: elevated bilirubin, increasing age, ascites, advanced fibrosis and the degree of portal bile stasis on liver biopsy. It was not possible to predict which asymptomatic patients would remain symptom free.
T C Mahl; W Shockcor; J L Boyer
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of hepatology     Volume:  20     ISSN:  0168-8278     ISO Abbreviation:  J. Hepatol.     Publication Date:  1994 Jun 
Date Detail:
Created Date:  1994-11-22     Completed Date:  1994-11-22     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8503886     Medline TA:  J Hepatol     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  707-13     Citation Subset:  IM    
Liver Study Unit, Yale University School of Medicine, New Haven, CT 06510.
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MeSH Terms
Follow-Up Studies
Life Tables
Liver Cirrhosis, Biliary / mortality*
Middle Aged
Multivariate Analysis
Risk Factors
Survival Analysis

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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