Document Detail


Primary biliary cirrhosis associated with mixed type autoimmune hemolytic anemia and sicca syndrome: a case report and review of literature.
MedLine Citation:
PMID:  9317084     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A case presenting with an unusual association of primary biliary cirrhosis and mixed type autoimmune hemolytic anemia plus sicca syndrome is described. The 49-yr-old female primary biliary cirrhosis patient had a confirmed sicca syndrome and presented with jaundice and life-threatening anemia. Laboratory tests revealed positive Coombs' test with coexisting cold and warm autoantibodies. She was successfully treated by blood transfusion with packed red cells lacking any red cell antigens corresponding to serum alloantibodies and pulse methylprednisolone therapy. The patient remained stable under maintenance treatment using oral steroids and ursodeoxycholic acid. This case is probably the first reported showing an association between primary biliary cirrhosis and mixed type autoimmune hemolytic anemia plus sicca syndrome and was probably induced by heterogenous and complicated autoimmune reactions.
Authors:
C Y Chen; C L Lu; C F Chiu; F Y Chang; S D Lee
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  The American journal of gastroenterology     Volume:  92     ISSN:  0002-9270     ISO Abbreviation:  Am. J. Gastroenterol.     Publication Date:  1997 Sep 
Date Detail:
Created Date:  1997-10-22     Completed Date:  1997-10-22     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0421030     Medline TA:  Am J Gastroenterol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1547-9     Citation Subset:  IM    
Affiliation:
Department of Medicine, Veterans General Hospital-Taipei and National Yang-Ming University, Taiwan.
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Anemia, Hemolytic, Autoimmune / complications*,  immunology,  therapy
Anti-Inflammatory Agents / administration & dosage,  therapeutic use
Antigens / immunology
Autoantibodies / analysis
Autoimmune Diseases / complications*,  immunology,  therapy
Blood Transfusion
Cholagogues and Choleretics / administration & dosage,  therapeutic use
Erythrocyte Transfusion
Erythrocytes / immunology
Female
Glucocorticoids / administration & dosage,  therapeutic use
Humans
Isoantibodies / immunology
Jaundice / etiology
Liver Cirrhosis, Biliary / complications*,  immunology,  therapy
Methylprednisolone / administration & dosage,  therapeutic use
Middle Aged
Sjogren's Syndrome / complications*,  immunology,  therapy
Treatment Outcome
Ursodeoxycholic Acid / administration & dosage,  therapeutic use
Chemical
Reg. No./Substance:
0/Anti-Inflammatory Agents; 0/Antigens; 0/Autoantibodies; 0/Cholagogues and Choleretics; 0/Glucocorticoids; 0/Isoantibodies; 128-13-2/Ursodeoxycholic Acid; 83-43-2/Methylprednisolone

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