Document Detail

Primary bile acid malabsorption. Histologic and immunologic study in three patients.
MedLine Citation:
PMID:  3569759     Owner:  NLM     Status:  MEDLINE    
Three patients are presented with a history of chronic watery diarrhea due to bile acid malabsorption, proved by the tauro-23[75Se]selena-25 homocholic acid test and an unequivocal response to cholestyramine therapy. Fecal fat tests, Schilling tests, and barium studies of the small intestine and colon were all normal. Jejunal biopsies were normal but multiple biopsies of the terminal ileum, performed by retrograde ileoscopy, showed uniform crypt hyperplastic villous atrophy and features of colonic metaplasia with increased mononuclear infiltration of the lamina propria. All 3 patients demonstrated evidence of abnormal immune function, including the presence of serum autoantibodies, circulating immune complexes, and hypocomplementemia. One patient had Sjögren's syndrome. This disorder, which might be immunologically mediated, should be called primary bile acid malabsorption and should be distinguished from other ileal disorders.
O S Popović; K M Kostić; V B Milović; S Milutinović-Djurić; V D Miletić; L Sesić; M Djordjević; M Bulajić; P Bojić; M Rubinić
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Gastroenterology     Volume:  92     ISSN:  0016-5085     ISO Abbreviation:  Gastroenterology     Publication Date:  1987 Jun 
Date Detail:
Created Date:  1987-06-15     Completed Date:  1987-06-15     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0374630     Medline TA:  Gastroenterology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1851-8     Citation Subset:  AIM; IM    
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MeSH Terms
Antibody Formation
Bile Acids and Salts / metabolism*
Cholestyramine Resin / therapeutic use
Diarrhea / etiology,  immunology,  pathology*
Ileum / pathology*
Intestinal Mucosa / pathology
Intestines / physiopathology
Malabsorption Syndromes / drug therapy,  immunology,  pathology*
Vitamin B 12 / metabolism
Reg. No./Substance:
0/Bile Acids and Salts; 11041-12-6/Cholestyramine Resin; 68-19-9/Vitamin B 12

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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