| Primary bile acid malabsorption. Histologic and immunologic study in three patients. | |
| | |
MedLine Citation:
|
PMID: 3569759 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Three patients are presented with a history of chronic watery diarrhea due to bile acid malabsorption, proved by the tauro-23[75Se]selena-25 homocholic acid test and an unequivocal response to cholestyramine therapy. Fecal fat tests, Schilling tests, and barium studies of the small intestine and colon were all normal. Jejunal biopsies were normal but multiple biopsies of the terminal ileum, performed by retrograde ileoscopy, showed uniform crypt hyperplastic villous atrophy and features of colonic metaplasia with increased mononuclear infiltration of the lamina propria. All 3 patients demonstrated evidence of abnormal immune function, including the presence of serum autoantibodies, circulating immune complexes, and hypocomplementemia. One patient had Sjögren's syndrome. This disorder, which might be immunologically mediated, should be called primary bile acid malabsorption and should be distinguished from other ileal disorders. |
| | |
Authors:
|
O S Popović; K M Kostić; V B Milović; S Milutinović-Djurić; V D Miletić; L Sesić; M Djordjević; M Bulajić; P Bojić; M Rubinić |
Related Documents
:
|
3895389 - Psychological aspects of non-ulcer dyspepsia: a psychosomatic view focusing on a compar... 20027679 - Elevated pro-inflammatory and lipotoxic mucosal lipids characterise irritable bowel syn... 18223499 - Bowel symptoms in nonerosive gastroesophageal reflux disease: nature, prevalence, and r... 19415159 - Potential extraperitoneal space continuous with the peri-intestinal space: ct evidence ... 8783099 - Management of the gastrointestinal tract and nutrition in patients with cloacal exstrophy. 2358619 - The response to dietary treatment of patients with chronic post-infectious diarrhea and... 22287149 - Prevalence and patterns of renal involvement in imaging of malignant lymphoproliferativ... 10947879 - Serum level of soluble tumour necrosis factor receptor ii (75 kda) indicates inflammato... 22808829 - Mitral annular geometry in normal and myxomatous mitral valves: three-dimensional trans... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Gastroenterology Volume: 92 ISSN: 0016-5085 ISO Abbreviation: Gastroenterology Publication Date: 1987 Jun |
Date Detail:
|
Created Date: 1987-06-15 Completed Date: 1987-06-15 Revised Date: 2009-11-19 |
Medline Journal Info:
|
Nlm Unique ID: 0374630 Medline TA: Gastroenterology Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 1851-8 Citation Subset: AIM; IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Antibody Formation Bile Acids and Salts / metabolism* Cholestyramine Resin / therapeutic use Diarrhea / etiology, immunology, pathology* Female Humans Ileum / pathology* Intestinal Mucosa / pathology Intestines / physiopathology Malabsorption Syndromes / drug therapy, immunology, pathology* Male Vitamin B 12 / metabolism |
| Chemical | |
Reg. No./Substance:
|
0/Bile Acids and Salts; 11041-12-6/Cholestyramine Resin; 68-19-9/Vitamin B 12 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Natural history of acute hepatitis B surface antigen-positive hepatitis in Greek adults.
Next Document: Immediate effects of furosemide on renal hemodynamics in chronic liver disease with ascites.