| Primary antiphospholipid syndrome presented by total infarction of right kidney with nephrotic syndrome. | |
| | |
MedLine Citation:
|
PMID: 10442498 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
We report the case of a young woman with primary antiphospholipid syndrome (APS), which presented with acute renal failure, hypoproteinemia, hypoalbuminemia and nephrotic proteinuria. Investigations showed total infarction of right kidney by extensive arterial and vein thrombosis and presence of anticardiolipin antibodies IgG isotype (anti-beta2-glycoprotein I-positive). She was submitted to right nefrectomy and initiated anticoagulant therapy. After nefrectomy, the postoperative period was marked by the development of arterial hypertension and persistence of nephrotic syndrome. Hypertension was treated with antihypertensive drugs (IECA, beta-blocker and calcium antagonist). As the nephrotic syndrome persisted despite anticoagulant and antihypertensive therapy, the patient was treated with oral corticosteroids. Her renal function improved, hypoproteinemia and hypoalbuminemia corrected to normal values and proteinuria decreased to subnephrotic value. We discuss the unusual presentation of this case of primary antiphospholipid syndrome with total unilateral renal thrombosis and nephrotic syndrome that respond to anticoagulant, antihypertensive and corticosteroid therapy. |
| | |
Authors:
|
H Sá; L Freitas; A Mota; F Cunha; A Marques |
Related Documents
:
|
1585938 - Glomerular capsular herniation in focal glomerular sclerosis. 10884998 - Nephrotic syndrome secondary to amyloidosis. 20046178 - Histopathological spectrum of childhood nephrotic syndrome in different hospitals of dh... 6459128 - Characterization of glycosaminoglycans in urine from patients with nephrotic syndrome a... 1603308 - Cranial ct and mri in diseases with dna repair defects. 1353118 - A case of simultaneous bilateral nonseminomatous testicular tumors in persistent mülle... |
Publication Detail:
|
Type: Case Reports; Journal Article; Review |
Journal Detail:
|
Title: Clinical nephrology Volume: 52 ISSN: 0301-0430 ISO Abbreviation: Clin. Nephrol. Publication Date: 1999 Jul |
Date Detail:
|
Created Date: 1999-09-28 Completed Date: 1999-09-28 Revised Date: 2005-11-16 |
Medline Journal Info:
|
Nlm Unique ID: 0364441 Medline TA: Clin Nephrol Country: GERMANY |
Other Details:
|
Languages: eng Pagination: 56-60 Citation Subset: IM |
Affiliation:
|
Nephrology Department, Hospitais da Universidade de Coimbra, Portugal. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adrenal Cortex Hormones / therapeutic use Antibodies, Anticardiolipin / isolation & purification Anticoagulants / therapeutic use Antihypertensive Agents / therapeutic use Antiphospholipid Syndrome / complications*, drug therapy, physiopathology Female Humans Infarction / etiology* Kidney / blood supply* Kidney Failure, Acute / etiology Nephrectomy Nephrotic Syndrome / etiology*, physiopathology, therapy Renal Artery / radiography |
| Chemical | |
Reg. No./Substance:
|
0/Adrenal Cortex Hormones; 0/Antibodies, Anticardiolipin; 0/Anticoagulants; 0/Antihypertensive Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Combined idiopathic retroperitoneal and mediastinal fibrosis with pericardial involvement.
Next Document: Bioequivalence of a generic metformin tablet preparation.