Document Detail

Primary angiitis of the central nervous system with diffuse cerebral mass effect and giant cells.
MedLine Citation:
PMID:  20303761     Owner:  NLM     Status:  MEDLINE    
Primary angiitis of the central nervous system (PACNS), also called primary CNS vasculitis, is an idiopathic inflammatory condition affecting only intracranial and spinal cord vessels, particularly medium-sized and smaller arteries and arterioles. Angiography and histopathology typically do not reveal evidence of systemic vasculitis.(1,2) Histopathology usually reveals granulomatous inflammation affecting arterioles and small arteries of the parenchyma and/or leptomeninges, similar to that seen in Takayasu's or giant cell arteritis.(1-3) We report a patient with biopsy-proven PACNS with giant cells and cerebral mass effect on MRI. Magnetic resonance angiography and cerebral angiography appeared normal and there was no evidence of extracranial vasculitis.
J A Kinsella; W O'Brien; G M Mullins; J Brewer; S Whyte
Publication Detail:
Type:  Case Reports; Journal Article     Date:  2010-03-19
Journal Detail:
Title:  Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia     Volume:  17     ISSN:  1532-2653     ISO Abbreviation:  J Clin Neurosci     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-03-29     Completed Date:  2010-06-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9433352     Medline TA:  J Clin Neurosci     Country:  Scotland    
Other Details:
Languages:  eng     Pagination:  674-6     Citation Subset:  IM    
Department of Neurology, The Adelaide and Meath Hospital, Dublin, Incorporating the National Children's Hospital, Trinity College Dublin, Tallaght, Dublin 24, Ireland. <>
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MeSH Terms
Aged, 80 and over
Anti-Inflammatory Agents / therapeutic use
Brain / pathology*,  radiography
Cerebral Angiography
Cerebrovascular Circulation
Giant Cells / pathology*
Magnetic Resonance Imaging
Prednisolone / therapeutic use
Treatment Outcome
Vasculitis, Central Nervous System / drug therapy,  pathology*,  radiography
Reg. No./Substance:
0/Anti-Inflammatory Agents; 50-24-8/Prednisolone

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