Document Detail


Primary amyloidosis presenting as upper limb multiple mononeuropathies.
MedLine Citation:
PMID:  20405503     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Peripheral neuropathy in primary (AL) amyloidosis is usually lower-limb predominant, length-dependent, symmetrical, and affects small (pain and autonomic) fibers, as much or more than large fibers. We report a patient with stepwise progressive, multiple upper limb mononeuropathies that were due to nerve biopsy-proven primary amyloidosis (lambda light chain), with no systemic or autonomic features. Recognition that light chain amyloidosis may be the cause of a multiple mononeuropathy pattern adds to the differential diagnosis of this clinical phenotype.
Authors:
Jennifer A Tracy; Peter J Dyck; P James B Dyck
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Muscle & nerve     Volume:  41     ISSN:  1097-4598     ISO Abbreviation:  Muscle Nerve     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-04-20     Completed Date:  2010-06-08     Revised Date:  2014-09-20    
Medline Journal Info:
Nlm Unique ID:  7803146     Medline TA:  Muscle Nerve     Country:  United States    
Other Details:
Languages:  eng     Pagination:  710-5     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Aged
Amyloid Neuropathies / pathology*,  physiopathology
Amyloidosis / complications,  pathology*,  physiopathology
Antibodies, Monoclonal / therapeutic use
Antibodies, Monoclonal, Murine-Derived
Arm / innervation,  physiopathology
Biological Markers / analysis,  metabolism
Biopsy
Diagnosis, Differential
Disease Progression
Electrodiagnosis
Female
Humans
Immunoglobulin Light Chains / analysis,  metabolism
Immunoglobulins, Intravenous / therapeutic use
Mononeuropathies / genetics,  pathology*,  physiopathology
Neural Conduction / physiology
Peripheral Nerves / metabolism,  pathology*,  physiopathology
Predictive Value of Tests
Sensitivity and Specificity
Treatment Failure
Grant Support
ID/Acronym/Agency:
NS36797/NS/NINDS NIH HHS; R01 NS036797/NS/NINDS NIH HHS; R01 NS036797-12/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Antibodies, Monoclonal, Murine-Derived; 0/Biological Markers; 0/Immunoglobulin Light Chains; 0/Immunoglobulins, Intravenous; 0/rituximab
Comments/Corrections

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