Document Detail

Primary amyloidosis (AL) presenting with nephrotic syndrome: a case report and discussion.
MedLine Citation:
PMID:  12762214     Owner:  NLM     Status:  MEDLINE    
Primary amyloidosis (AL) is a rare disorder with only eight cases per million a year. AL is a plasma cell disorder in which neoplastic clonal plasma cells in the bone marrow produce monoclonal immunoglobulin light chains that form protease resistant amyloid fibrils. AL fibrils accumulate within tissues systemically, causing progressive organ impairment to ultimate death. Median survival in AL with treatment is only 17 months depending upon variable prognostic factors. Most patients present with nephrotic syndrome and associated peripheral edema because the kidney is the most common organ involved in AL. This article describes the case of a patient who presented to City Hospital in Martinsburg, W.Va., and was diagnosed with primary amyloidosis, and reviews the current literature on this illness.
Lisa Musolin; Roberto Reyna; Jeffrey DeBord
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  The West Virginia medical journal     Volume:  99     ISSN:  0043-3284     ISO Abbreviation:  W V Med J     Publication Date:    2003 Jan-Feb
Date Detail:
Created Date:  2003-05-23     Completed Date:  2003-07-03     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0413777     Medline TA:  W V Med J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  28-30     Citation Subset:  IM    
West Virginia School of Osteopathic Medicine, Lewisburg, USA.
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MeSH Terms
Amyloidosis / complications*,  drug therapy
Edema / drug therapy,  etiology
Fatigue / etiology
Hypercholesterolemia / complications
Middle Aged
Nephrotic Syndrome / complications*

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