Document Detail

Primary amoebic meningoencephalitis.
MedLine Citation:
PMID:  342849     Owner:  NLM     Status:  MEDLINE    
As a serendipitous by-product of polio virus research, a highly fatal amoebic meningoencephalitis was recognized in animals. The causative microorganisms, contaminants of the viral cultures, were identified as small soil amoebae. These organisms, previously considered non-pathogenic, are prevalent throughout the world. Based on animal studies, the original investigators suggested the possibility of a similar disease in humans. Seven years later, human cases of amoebic meningoencephalitis were reported from widely separated areas of the world. Since 1965, a total of 79 cases have been reported. The literature of primary amoebic meningoencephalitis is presented. The history of the discovery and elucidation of this disease is reviewed. The 79 cases reported in the world literature are divided into two groups, those diagnosed retrospectively after reviewing previous deaths from meningoencephalitis, and those diagnosed at the time of the illness. The classification, morphology, pathogenicity, virulence and distribution of pathogenic soil amoebae are reviewed. The presenting clinical findings, diagnostic procedures, pathology, and management of this recently recognized, highly fatal, human disease is presented along with a report of a new case. Otolaryngologists should become familiar with this serious disorder with a transnasal portal of entry.
M W Lockey
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  The Laryngoscope     Volume:  88     ISSN:  0023-852X     ISO Abbreviation:  Laryngoscope     Publication Date:  1978 Mar 
Date Detail:
Created Date:  1978-04-26     Completed Date:  1978-04-26     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8607378     Medline TA:  Laryngoscope     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  484-503     Citation Subset:  IM    
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MeSH Terms
Amebiasis* / diagnosis,  pathology,  therapy
Amoeba / classification,  isolation & purification,  pathogenicity
Brain / pathology
Hartmannella / classification,  pathogenicity
Meningoencephalitis / diagnosis,  etiology*,  pathology,  therapy
Soil Microbiology
Water Microbiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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