Document Detail

Primary amenorrhea and pituitary adenomas.
MedLine Citation:
PMID:  7195827     Owner:  NLM     Status:  MEDLINE    
From 1972 to 1980, 210 patients underwent transsphenoidal operation for removal of a prolactin-secreting tumor. Eight of the patients had primary amenorrhea. All eight patients had had a normal thelarche and pubarche without menarche, and all eight had hyperprolactinemia and abnormal findings on sella turcica tomography. After operation, only one patient did not have persistent hyperprolactinemia, and this patient was the only one who began spontaneous menses. The data indicate that although prolactin hypersecretion interferes with menstrual function, it does not alter other pubertal development and that, if the source of the excessive prolactin can be removed, the removal alone may initiate spontaneous menses. In this report, however, patients with prolactin-secreting adenomas and primary amenorrhea had a high incidence of persistent hyperprolactinemia after operation (seven of eight patients).
C B Coulam; E R Laws; C F Abboud; R V Randall
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Fertility and sterility     Volume:  35     ISSN:  0015-0282     ISO Abbreviation:  Fertil. Steril.     Publication Date:  1981 Jun 
Date Detail:
Created Date:  1981-09-15     Completed Date:  1981-09-15     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  615-9     Citation Subset:  IM    
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MeSH Terms
Adenoma / complications*,  pathology
Amenorrhea / complications*
Follow-Up Studies
Galactorrhea / complications
Pituitary Neoplasms / complications*,  pathology
Prolactin / blood
Tomography, X-Ray Computed
Reg. No./Substance:

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