Document Detail

Primary aldosteronism - treatment options.
MedLine Citation:
PMID:  12914736     Owner:  NLM     Status:  MEDLINE    
Diagnosis of primary aldosteronism results in either the surgical cure of hypertension or targeted pharmacotherapy. The two major subtypes of primary aldosteronism are unilateral aldosterone-producing adenoma (APA) and bilateral idiopathic hyperaldosteronism (IHA). Patients with APA usually are treated with unilateral adrenalectomy and patients with IHA are treated medically. The majority of patients with primary aldosteronism have the IHA subtype and require pharmacotherapy. Spironolactone has been the drug of choice to treat primary aldosteronism. However, it is not selective for the aldosterone receptor, and side effects include gynecomastia, erectile dysfunction and menstrual irregularity. Eplerenone is a new competitive and selective aldosterone receptor antagonist recently approved by the United States Food and Drug Administration for the treatment of hypertension. It lacks the side effects associated with spironolactone and will be the superior drug if it is shown to be as effective as spironolactone for the treatment of mineralocorticoid-dependent hypertension.
William F Young
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society     Volume:  13 Suppl A     ISSN:  1096-6374     ISO Abbreviation:  Growth Horm. IGF Res.     Publication Date:  2003 Aug 
Date Detail:
Created Date:  2003-08-13     Completed Date:  2004-05-13     Revised Date:  2009-11-03    
Medline Journal Info:
Nlm Unique ID:  9814320     Medline TA:  Growth Horm IGF Res     Country:  Scotland    
Other Details:
Languages:  eng     Pagination:  S102-8     Citation Subset:  IM    
Divisions of Endocrinology, Metabolism, Nutrition and Internal Medicine, Mayo Medical School, Mayo Clinic and Mayo Foundation, 200 First Street S.W., Rochester, MN 55905, USA.
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MeSH Terms
Hyperaldosteronism / complications,  diagnosis,  therapy*
Hypertension / diagnosis,  etiology,  therapy
Hypokalemia / diagnosis,  etiology,  therapy

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