| Primary aldosteronism and its impact on the generation of arterial hypertension, endothelial injury and oxidative stress. | |
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MedLine Citation:
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PMID: 20583536 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Aldosterone plays an important role in blood pressure homeostasis, the regulation of circulating volume, and the maintenance of the sodium-potassium balance by binding to the mineralocorticoid receptor (MR). Primary aldosteronism (PA) states are associated with an increased cardiovascular risk, mediated not only by hypertension but also by the action of aldosterone in the modulation of vasodilation/vasoconstriction and oxidative stress. In this review, we discuss some of the cardiovascular actions of aldosterone and the most frequent causes of PA. |
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Authors:
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Alejandro Martinez-Aguayo; Cristian A Carvajal; Carmen Campino; Marlene Aglony; Lillian Bolte; Hernán Garcia; Carlos E Fardella |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Journal of pediatric endocrinology & metabolism : JPEM Volume: 23 ISSN: 0334-018X ISO Abbreviation: J. Pediatr. Endocrinol. Metab. Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-06-29 Completed Date: 2010-07-12 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9508900 Medline TA: J Pediatr Endocrinol Metab Country: England |
Other Details:
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Languages: eng Pagination: 323-30 Citation Subset: IM |
Affiliation:
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Endocrinology Unit, Department of Paediatrics, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Endothelium, Vascular
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physiopathology* Humans Hyperaldosteronism / blood, complications, physiopathology* Hypertension / blood, etiology*, physiopathology Oxidative Stress* |
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