Document Detail


Primary aldosteronism and its impact on the generation of arterial hypertension, endothelial injury and oxidative stress.
MedLine Citation:
PMID:  20583536     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Aldosterone plays an important role in blood pressure homeostasis, the regulation of circulating volume, and the maintenance of the sodium-potassium balance by binding to the mineralocorticoid receptor (MR). Primary aldosteronism (PA) states are associated with an increased cardiovascular risk, mediated not only by hypertension but also by the action of aldosterone in the modulation of vasodilation/vasoconstriction and oxidative stress. In this review, we discuss some of the cardiovascular actions of aldosterone and the most frequent causes of PA.
Authors:
Alejandro Martinez-Aguayo; Cristian A Carvajal; Carmen Campino; Marlene Aglony; Lillian Bolte; Hernán Garcia; Carlos E Fardella
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Journal of pediatric endocrinology & metabolism : JPEM     Volume:  23     ISSN:  0334-018X     ISO Abbreviation:  J. Pediatr. Endocrinol. Metab.     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-06-29     Completed Date:  2010-07-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9508900     Medline TA:  J Pediatr Endocrinol Metab     Country:  England    
Other Details:
Languages:  eng     Pagination:  323-30     Citation Subset:  IM    
Affiliation:
Endocrinology Unit, Department of Paediatrics, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.
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MeSH Terms
Descriptor/Qualifier:
Endothelium, Vascular / physiopathology*
Humans
Hyperaldosteronism / blood,  complications,  physiopathology*
Hypertension / blood,  etiology*,  physiopathology
Oxidative Stress*

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