| Primary aldosteronism: cardiovascular, renal and metabolic implications. | |
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MedLine Citation:
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PMID: 18314347 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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For many years primary aldosteronism was considered a relatively benign form of hypertension. This assumption reflects the primacy accorded to elevated levels of angiotensin in terms of deleterious cardiovascular effects, and the fact that in primary aldosteronism renin and angiotensin levels are low. We now know that primary aldosteronism causes a constellation of cardiovascular, renal and metabolic sequelae which make it far from benign and that these are not merely effects of blood pressure elevation. In primary aldosteronism, tissue damage, on several indices, is higher than in age-, sex- and blood pressure-matched controls, reflecting the ability of inappropriately elevated aldosterone for salt status to produce structural and functional changes over and above those produced by high blood pressure. |
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Authors:
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Gian-Paolo Rossi; Leonardo A Sechi; Gilberta Giacchetti; Vanessa Ronconi; Pasquale Strazzullo; John W Funder |
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Publication Detail:
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Type: Journal Article; Review Date: 2008-03-07 |
Journal Detail:
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Title: Trends in endocrinology and metabolism: TEM Volume: 19 ISSN: 1043-2760 ISO Abbreviation: Trends Endocrinol. Metab. Publication Date: 2008 Apr |
Date Detail:
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Created Date: 2008-04-03 Completed Date: 2008-06-26 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9001516 Medline TA: Trends Endocrinol Metab Country: United States |
Other Details:
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Languages: eng Pagination: 88-90 Citation Subset: IM |
Affiliation:
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DMCS - Clinica Medica 4 and University of Padua, 35126, Padua, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Cardiovascular System
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physiopathology* Humans Hyperaldosteronism / complications, physiopathology* Hypertension / etiology Kidney / physiopathology* Metabolic Syndrome X / etiology Risk Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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