Document Detail

Primary adrenal lymphoma associated with adrenal insufficiency: a distinct clinical entity.
MedLine Citation:
PMID:  9156667     Owner:  NLM     Status:  MEDLINE    
We describe a case of a 42 year old male who presented with Addison's disease resulting from primary lymphoma of the adrenals. Our case and a review of the literature indicates that this distinct entity has some unique clinical and radiologic features. In this entity, the lymphoma tends to be extranodal and have a poor prognosis. In addition, the computed tomography (CT) images have the unique appearance of enlargement of the adrenal gland with maintenance of the adreniform shape. We suggest that primary adrenal lymphoma is a distinct clinical entity and should be considered in patients with an elevated serum lactate dehydrogenase, characteristic CT findings and Addison's disease.
M Pimentel; J B Johnston; D R Allan; H Greenberg; C N Bernstein
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Leukemia & lymphoma     Volume:  24     ISSN:  1042-8194     ISO Abbreviation:  Leuk. Lymphoma     Publication Date:  1997 Jan 
Date Detail:
Created Date:  1997-05-20     Completed Date:  1997-05-20     Revised Date:  2006-04-24    
Medline Journal Info:
Nlm Unique ID:  9007422     Medline TA:  Leuk Lymphoma     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  363-7     Citation Subset:  IM    
Department of Medicine, University of Manitoba, Winnipeg, Canada.
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MeSH Terms
Addison Disease / blood,  etiology*
Adrenal Cortex Neoplasms / blood,  complications*,  diagnosis,  drug therapy,  pathology
Adrenal Gland Diseases / diagnosis
Antineoplastic Combined Chemotherapy Protocols / therapeutic use
Cosyntropin / diagnostic use
Cyclophosphamide / administration & dosage
Dexamethasone / administration & dosage
Diagnosis, Differential
Doxorubicin / administration & dosage
Etoposide / administration & dosage
Eye Neoplasms / drug therapy,  pathology,  radiography
Fatal Outcome
Hydrocortisone / blood
Hyperkalemia / etiology
Ifosfamide / administration & dosage
L-Lactate Dehydrogenase / blood
Lymphoma, T-Cell / blood,  complications*,  diagnosis,  drug therapy,  pathology
Methotrexate / administration & dosage
Neoplasm Proteins / blood
Oculomotor Muscles / pathology,  radiography
Prednisone / administration & dosage
Tomography, X-Ray Computed
Tuberculosis, Endocrine / diagnosis
Tumor Markers, Biological / blood
Vincristine / administration & dosage
Reg. No./Substance:
0/CHOP protocol; 0/Neoplasm Proteins; 0/Tumor Markers, Biological; 16960-16-0/Cosyntropin; 23214-92-8/Doxorubicin; 33419-42-0/Etoposide; 3778-73-2/Ifosfamide; 50-02-2/Dexamethasone; 50-18-0/Cyclophosphamide; 50-23-7/Hydrocortisone; 53-03-2/Prednisone; 57-22-7/Vincristine; 59-05-2/Methotrexate; EC Dehydrogenase

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