Document Detail

Primary adenocarcinoma of the seminal vesicle.
Jump to Full Text
MedLine Citation:
PMID:  19468449     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Primary adenocarcinomas of the seminal vesicle (SVC) are very rare and poorly understood neoplasms with only somewhat more than 50 histologically confirmed cases reported in the literature. We demonstrate a case of SVC and discuss the problems related to diagnosis in this tumor.
M Tarján; I Ottlecz; T Tot
Related Documents :
1775409 - Clubbing associated with oesophageal adenocarcinoma.
6799049 - Survey of sickle-cell disease in england and wales.
21358869 - Scar endometriosis - a rare cause for a painful scar: a case report and review of the l...
15677969 - Trichoblastoma with apocrine and sebaceous differentiation.
3603319 - Giant hydronephrosis causing contralateral ureteric obstruction. a case report.
18031949 - Usefulness of hypoxia inducible factor-1 alpha in evaluating the prostatic adenocarcino...
1757069 - Lethal arthrogryposis multiplex congenita: a pathological study of 21 cases.
12041819 - Miliary osteoma of the face: a report of 4 cases and review of the literature.
10380139 - Occurrence of familial nonarteritic anterior ischemic optic neuropathy in a case series.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Indian journal of urology : IJU : journal of the Urological Society of India     Volume:  25     ISSN:  0970-1591     ISO Abbreviation:  Indian J Urol     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2009-05-26     Completed Date:  2011-07-14     Revised Date:  2013-05-23    
Medline Journal Info:
Nlm Unique ID:  8510441     Medline TA:  Indian J Urol     Country:  India    
Other Details:
Languages:  eng     Pagination:  143-5     Citation Subset:  -    
Department of Pathology and Clinical Cytology, Central Hospital, Falun, Sweden.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Full Text
Journal Information
Journal ID (nlm-ta): Indian J Urol
Journal ID (publisher-id): IJU
ISSN: 0970-1591
ISSN: 1998-3824
Publisher: Medknow Publications, India
Article Information
? Indian Journal of Urology
open-access: This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Print publication date: Season: Jan?Mar Year: 2009
Volume: 25 Issue: 1
First Page: 143 Last Page: 145
ID: 2684320
PubMed Id: 19468449
Publisher Id: IJU-25-143
DOI: 10.4103/0970-1591.45557

Primary adenocarcinoma of the seminal vesicle
M. Tarj?nAF0001
I. Ottlecz1
T. TotAF0001
Department of Pathology and Clinical Cytology, Central Hospital, Falun, Sweden
1Department of Urology Toldy Ferenc Hospital, Cegl?d, Hungary
Correspondence: For correspondence: Dr. Mikl?s Tarj?n, Department of Pathology and Clinical Cytology, Central Hospital, Falun, S-791 82 Falun, Sweden. E-mail:


Primary adenocarcinomas of the seminal vesicle (SVC) are very rare and poorly understood neoplasms with only somewhat more than 50 histologically confirmed cases reported in the literature.[1] We demonstrate a case of SVC and discuss the problems related to diagnosis in this tumor.


A 54-year-old man with dysuria and haematuria was first examined in January 2007. Laboratory parameters including serum prostate specific antigen (PSA) level were normal. Digital rectal examination detected a poorly defined hard tumoral mass on the site of the left seminal vesicle, under the intact rectal mucosa. This finding was confirmed by ultrasonography. Primary rectal tumor was ruled out by colonoscopy. Microscopic analysis of the colon biopsy showed infiltration of poorly differentiated adenocarcinoma restricted to submucosa with no evidence of tumor or dysplastic change in the mucosa.

Contrast-enhanced magnetic resonance imaging was performed, which demonstrated a tumor mass in the area of left seminal vesicle, partly affecting the prostate and the anterior wall of the rectum [Figure 1]. The patient underwent transrectal core biopsy, which histologically showed desmoplastic stroma and fatty tissue infiltrated by the structures of poorly differentiated adenocarcinoma in close relation to the structures of a normal seminal vesicle [Figure 2]. Immunohistochemical analysis evidenced positive reactions with carcinoembryonic antigen (CEA) and cytokeratin 7 in almost all tumor cells, but negative reactions with PSA, CDX2, cytokeratin 20, CA-125 and androgen receptors.

Chest X ray and computed tomography (CT) of abdomen were also performed without showing any signs of malignancy. No previous diagnosis of malignant disease was registered in the patient's files. The clinical, radiological, histological, and immunohistological findings were consistent with primary SVC. The expert team of urological oncologists proposed radiotherapy before surgical intervention. However, the patient died of the disease 12 months after the histological diagnosis. Autopsy was not performed because relatives requested it.


In 1956, Dalgaard and Giertson[2] established the following criteria for a diagnosis of SVC:

  1. The tumor should be a microscopically verified carcinoma, localized exclusively or mainly to the seminal vesicle.
  2. The presence of other simultaneous primary carcinoma should be excluded.
  3. The tumor should preferably resemble the architecture of the non-neoplastic seminal vesicle.

These criteria can be readily applied to surgical resection specimens, but are less suitable in evaluating radiologically guided needle biopsies. Immunostains are helpful in these circumstances but vesicula-specific markers are not available.[3]

While primary SVCs are rare, secondary neoplastic involvement of the seminal vesicle is not so infrequent. Moreover, when clinical symptoms occur in a patient with SVC, they often reflect advanced disease with infiltration of adjacent organs obscuring the vesicular origin of the tumor. The most common symptoms are non-specific. These are hematuria and hematospermia, but dysuria; painful defecation and general pelvic pain have also been reported.[1] CT scan, magnetic resonance imaging and ultrasonography may be helpful in localizing the tumor. In early stage of the disease these radiologic examinations can help to exclude carcinoma of the adjacent organs, like prostate, rectum or urinary bladder. The modern radiological examinations might also demonstrate the epicentre of tumor in advanced stage of disease.

Histological examination is central in diagnosing SVC, despite the lack of organ-specific immunofenotype. Immunohistochemistry is rather helpful to exclude some metastatic tumors than to confirm the origin of the tumor in seminal vesicle [Table 1]. The common histological variant of SVC is well-differentiated adenocarcinoma with papillary structures[3, 4] but poorly differentiated carcinomas similar to our case have also been described.[3, 5] The related literature is concordant in the fact that SVC is negative for PSA and also for anti-prostate specific acid phosphatase (PSAP). As the seminal vesicles are often invaded by prostatic adenocarcinoma, the lack of PSA immunostaining in SVC is very useful differential diagnostic clue, but does not completely exclude anaplastic prostatic adenocarcinoma, which may be PSA negative.[5] SVC usually expresses CK7 but not CK 20. Importantly, the rare non-enteric type of bladder adenocarcinoma and adenocarcinoma arising in m?llerian duct cyst are also CK7 positive and CK20 negative. In addition, ductal-type of prostatic cancers is PSA positive but usually these tumors are CK7 and CK20 negative. The lack of CK20 immunoreactivity in SVC is helpful in distinguishing these tumors from colorectal adenocarcinoma and urothelial-type bladder carcinoma, usually expressing CK20.

According to the reported data in the literature, the immunohistohemical profile of SVC is not as consistent regarding other tumor markers as for PSA, CK7, and CK20.[3, 5] Carcinoembryonic antigen (CEA) was expressed in most reported cases of SVC, including our case.[1, 5] Most well-differentiated papillary SVCs are CA-125 positive, while poorly differentiated SVCs, like our case, do not express this marker of m?llerian duct differentiation.[3, 5] Thus m?llerian duct cyst adenocarcinoma originated in seminal vesicle may be indistinguishable from conventional SVC. The most useful antibodies and their expression in tumors representing the differential diagnostic options are summarized in Table 1.

In summary, the diagnosis of SVC is based on correlation of clinical, radiological, and histological findings. Immunohistochemistry may be helpful in ruling out some differential diagnostic options but cannot per se distinguish poorly differentiated SVC from metastatic spread of poorly differentiated carcinoma of prostate, certain adenocarcinomas of urinary bladder and from the rare carcinomas originating in m?llerian duct cyst.


Source of Support: Nil

Conflict of Interest: None declared.

1. Egevad L,Ehrnstr?m R,H?kansson U,Grabe M. Primary seminal vesicle carcinoma detected at transurethral resection of prostateUrology 2007;69:778e11–3. [pmid: 17445673]
2. Dalgaard JB,Giertson JC. Primary carcinoma of the seminal vesicle: Case and surveyActa Pathol Microbiol Scand 1956;39:255–67. [pmid: 13381470]
3. Ormsby AH,Haskell R,Jones D,Goldblum JR. Primary seminal vesicle carcinoma: An immunohistochemical analysis of four casesMod Pathol 2000;13:46–51. [pmid: 10658909]
4. Ohmori T,Okada K,Tabei R,Sugiura K,Nabeshima S,Ohoka H,Okamoto M. CA 125-producing adenocarcinoma of the seminal vesiclePathol Int 1994;44:333–7. [pmid: 8044301]
5. Oxley JD,Brett MT,Gillatt DA,Burton P. Seminal vesivle carcinomaHistopathology 1999;34:562–3. [pmid: 10383707]


[Figure ID: F0001]
Figure 1 

Contrast-enhanced magnetic resonance image demonstrating a tumor mass in the area of the left seminal vesicle, slightly affecting the prostate and the anterior wall of rectum

[Figure ID: F0002]
Figure 2A 

Low magnification histology image of the poorly differentiated tumor infiltrating the surrounding tissue of seminal vesicle (H&E, ?40)

[Figure ID: F0003]
Figure 2B 

Reprepresentative high-power histology image showing poorly differentiated adenocarinoma with desmoplastic stroma (H&E, ?100)

[TableWrap ID: T0001] Table 1 

Immunohistochemical profile of seminal vesicle adenocarcinoma compared to the profile of the tumors representing the most common differential diagnostic options

Cytokeratin7 Cytokeratin20 CA-125 CEA PSA CDX2
Seminal vesicle cancer + ? +* +/? ? ?
Prostate cancer ?** ? ? ? + ?
Rectal cancer ? + ? + ? +
Urinary bladder adenocarcinoma +? ??? ?/+ ? ???
M?llerian duct adenocarcinoma + ? +/? +/? ? ?

*Poorly differentiated tumors are negative

**ductal type prostate cancers may be positive

?enteric types urinary bladder adenocarcinomas are negative

??enteric types urinary bladder adenocarcinomas are positive

Article Categories:
  • Uropathology

Keywords: Adenocarcinoma, differential diagnosis, seminal vesicle.

Previous Document:  Laparoscopic ureterolithotomy for lower ureteric stones: Steps to make it a simple procedure.
Next Document:  Prostatic fascia and recovery of sexual function after radical prostatectomy: Is it a "Veil of Aphro...