| Primary T-cell rich B-cell lymphoma of the common bile duct. | |
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MedLine Citation:
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PMID: 8291224 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A 34-year-old woman was hospitalized for the investigation of a one-month history of intestinal disorders, gastric heaviness and transitory icteric episodes. Extensive clinical investigations suggested the diagnosis of gall bladder carcinoma or sclerosing cholangitis. At laparotomy, the proximal part of common bile duct was markedly thickened by a white, firm, fish-flesh like tumour extending in to the cystic duct, gall bladder wall and to the liver. Histological study showed a diffuse lymphoid proliferation of the common bile duct mainly composed of small cells mixed with scattered large atypical cells. Immunohistochemistry revealed that most of the small cells expressed T-cell markers with predominant CD 4 and alpha-beta T-cell receptors and without phenotypic gap, whereas large atypical cells showed monotypic B phenotype with co-expression of mu and delta heavy chains and light lambda chain restriction. No evidence of primary nodal lymphoma was found during extensive clinical, radiological, sonographic or scanographic examinations. Sequential chemotherapy (MACOP-B) was instituted and the patient was still alive 4 years after diagnosis. Morphological and immunohistochemistry findings fulfilled criteria for a primary high grade B-cell lymphoma (centroblastic type, Kiel classification) from common bile duct concealed by numerous small reactive T-cells, so called T-cell rich B-cell lymphoma, not previously described in this location. |
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Authors:
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J P Brouland; J Molimard; J Nemeth; P Valleur; A Galian |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Virchows Archiv. A, Pathological anatomy and histopathology Volume: 423 ISSN: 0174-7398 ISO Abbreviation: Virchows Arch A Pathol Anat Histopathol Publication Date: 1993 |
Date Detail:
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Created Date: 1994-02-22 Completed Date: 1994-02-22 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8302198 Medline TA: Virchows Arch A Pathol Anat Histopathol Country: GERMANY |
Other Details:
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Languages: eng Pagination: 513-7 Citation Subset: IM |
Affiliation:
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Service Central d'Anatomie et de Cytologie Pathologiques, Hôpital Lariboisière, Paris, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antigens, CD / analysis Bile Duct Neoplasms / chemistry, pathology* Female Humans Lymphoma, B-Cell / chemistry, pathology* T-Lymphocytes / chemistry, pathology* |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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