Document Detail


Primary study on mode of action for macrocyclic fungicide candidates (7B3, D1) against Rhizoctonia solani Kuhn.
MedLine Citation:
PMID:  20050666     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A novel macrolactam fungicide candidate (7B3) and a novel aza-macrolactone fungicide candidate (D1) were designed and synthesized, and the bioassay showed that both displayed excellent fungicidal activity against Rhizoctonia solani Kuhn. To elucidate the biochemical mode of action of the two compounds against R. solani and illustrate the similarities and differences of action mechanism resulting from subtle differences in structure of the two compounds, the effects of the two compounds on the ultrastructure of hyphae, electrolyte leakage, and respiration of mycelia cell suspension caused by 7B3 or D1 were studied. The results showed that the two compounds had very similar modes of action. Both induced irregular swelling of hyphae, vacuolation of cytoplasm, and thickening of cell wall. The conductivity of mycelia cell suspension increased in the presence of 7B3 or D1, which indicated that the two compounds had a similar effect on cell membrane permeability. In addition, both 7B3 and D1 were insufficient in inhibiting the respiration of mycelia.
Authors:
Xiaojing Yan; Xiaomei Liang; Shuhui Jin; Jinping Lv; Chunxin Yu; Wenyan Qi; Baoju Li; Huizhu Yuan; Shuhua Qi; Yanxia Shi; Jingping Wu; Fuheng Chen; Daoquan Wang
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of agricultural and food chemistry     Volume:  58     ISSN:  1520-5118     ISO Abbreviation:  J. Agric. Food Chem.     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-03-03     Completed Date:  2010-07-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0374755     Medline TA:  J Agric Food Chem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2726-9     Citation Subset:  IM    
Affiliation:
Key Laboratory of Pesticide Chemistry and Application Technology, Department of Applied Chemistry, China Agricultural University, Beijing 100193, People's Republic of China.
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MeSH Terms
Descriptor/Qualifier:
Fungicides, Industrial / pharmacology*
Macrocyclic Compounds / pharmacology*
Microscopy, Electron, Scanning
Microscopy, Electron, Transmission
Rhizoctonia / drug effects*,  ultrastructure
Chemical
Reg. No./Substance:
0/Fungicides, Industrial; 0/Macrocyclic Compounds

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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