Document Detail

Primary prevention of variceal hemorrhage.
MedLine Citation:
PMID:  21086193     Owner:  NLM     Status:  In-Data-Review    
Variceal hemorrhage is one of the leading causes of death in patients with cirrhosis, with the 6-week mortality after each episode ranging from 15% to 20%. The two main strategies for primary prevention of variceal bleeding in patients with cirrhosis and varices are the administration of nonselective β-blockers or the obliteration of varices with use of endoscopic band ligation. In this review, we present and critically review the latest data on primary prevention of variceal hemorrhage. We advocate that nonselective β-blockers should be the first line therapy, and band ligation should be offered only in cases of intolerance or side effects. We also explore potential future therapies based on preliminary experimental and clinical data.
Emmanuel A Tsochatzis; Christos K Triantos; Matteo Garcovich; Andrew K Burroughs
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Current gastroenterology reports     Volume:  13     ISSN:  1534-312X     ISO Abbreviation:  Curr Gastroenterol Rep     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-01-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100888896     Medline TA:  Curr Gastroenterol Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3-9     Citation Subset:  IM    
The Royal Free Sheila Sherlock Liver Centre and University Department of Surgery, Royal Free Hospital and UCL, Pond Street, Hampstead, London, NW3 2QG, UK,
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