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Primary Monophasic Synovial Sarcoma of the Tonsil: Immunohistochemical and Molecular Study of a Case and Review of the Literature.
MedLine Citation:
PMID:  23564530     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Synovial sarcoma (SS) arises primarily in the lower extremities with a predilection for sites in proximity to large joints, such as the knee. It rarely occurs in the head and neck region, and the tonsil is an unusual site for the tumor, with only eight previously published cases in this anatomical site. We present a case of a primary monophasic SS arising in the right tonsil in a 63-year-old male. His medical history was noncontributory. Immunohistochemistry showed that cytokeratin OSCAR, EMA, Bcl-2, vimentin, PGP 9.5, and TLE1 were diffusely positive. A molecular analysis using RT-PCR indicated that the patient was positive for the SYT/SSX1 fusion transcript. A diagnosis of monophasic synovial sarcoma of the tonsil was made.
Authors:
Danny Soria-Céspedes; Aldo Iván Galván-Linares; Cuauhtemoc Oros-Ovalle; Francisco Gaitan-Gaona; Carlos Ortiz-Hidalgo
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-4-7
Journal Detail:
Title:  Head and neck pathology     Volume:  -     ISSN:  1936-0568     ISO Abbreviation:  Head Neck Pathol     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-4-8     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101304010     Medline TA:  Head Neck Pathol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Pathology, The American British Cowdray Medical Center, Sur 136#116. Col Las Américas, 01120, Mexico, DF, Mexico.
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