Document Detail

Primary metastatic leiomyosarcoma of the fallopian tube: a rare case report.
MedLine Citation:
PMID:  20164662     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Leiomyosarcoma of the fallopian tube is an extremely unusual gynecologic neoplasm. Since 1886, only 19 of about 35 sarcomas of the fallopian tube have been identified as leiomyosarcomas. As such, clinical diagnosis and therapy management are difficult. CASE REPORT: We report on the case of a 59-year-old woman with leiomyosarcoma of the fallopian tube and liver metastases at the time of diagnosis. After initial tumor debulking, she received palliative chemotherapy with gemcitabine 900 mg/m(2) (d1+8) and docetaxel 100 mg/m(2) (d8) (q21). For additional bone metastases, she started local radiation plus bisphosphonates (q28). After 2 cycles of chemotherapy, the disease progressed, and the patient died within 8 months of diagnosis. A review of the literature is given. CONCLUSIONS: Primary metastatic leiomyosarcoma of the fallopian tube is a progressive disease with limited therapy options. For better prognostic evaluation and disease management in such rare cases, it is important to report and compare more cases regarding course of disease and outcome.
Volker R Jacobs; Iris Zemzoum; Marcus Kremer; Nina Gottschalk; Anne K Baumg?rtner; Janna Krol; Marion Kiechle
Publication Detail:
Type:  Case Reports; Journal Article; Review     Date:  2010-01-22
Journal Detail:
Title:  Onkologie     Volume:  33     ISSN:  1423-0240     ISO Abbreviation:  Onkologie     Publication Date:  2010  
Date Detail:
Created Date:  2010-02-18     Completed Date:  2010-06-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7808556     Medline TA:  Onkologie     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  49-52     Citation Subset:  IM    
Copyright Information:
(c) 2010 S. Karger AG, Basel.
Department of Obstetrics and Gynecology, Technical University Munich, Germany.
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MeSH Terms
Combined Modality Therapy
Diagnostic Imaging
Disease Progression
Fallopian Tube Neoplasms / diagnosis*,  pathology,  therapy
Fallopian Tubes / pathology
Fatal Outcome
Leiomyosarcoma / diagnosis,  pathology,  secondary*,  therapy
Liver / pathology
Liver Neoplasms / diagnosis,  pathology,  secondary*,  therapy
Middle Aged
Neoplasm Invasiveness / pathology
Neoplasm Staging
Palliative Care
Peritoneal Neoplasms / diagnosis,  pathology,  secondary*,  therapy

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