Document Detail

Primary Leiomyoma of the pleura.
Jump to Full Text
MedLine Citation:
PMID:  21752306     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Primary leiomyoma of the pleura is extremely rare. A 45-year-old man presented with a complaint of right chest pain. Chest computed tomography demonstrated a solid, round pleural mass in the right anterior chest wall. The mass was completely resected, and histopathological examination revealed a localized primary pleural leiomyoma. The patient was followed and has been disease-free for over 15 months. This is the first report of primary leiomyoma of the pleura in China. A review of the literature on primary leiomyoma of the pleura is presented.
Authors:
Xiaoming Qiu; Daxin Zhu; Sen Wei; Gang Chen; Jun Chen; Qinghua Zhou
Related Documents :
7217976 - Myotonic dystrophy and thymoma: a necropsy case report.
21407846 - Risperidone - induced tardive dyskinesia : case report and review of literature.
15557526 - Progressive prosopagnosia: clinical and neuroimaging results.
17361336 - Cerebral erdheim-chester disease: first report of child with slowly progressive cerebel...
8040466 - Giant folliculosebaceous cystic hamartoma.
1342056 - Ten years of forensic odontology: a report from the department of forensic odontology, ...
Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-07-14
Journal Detail:
Title:  World journal of surgical oncology     Volume:  9     ISSN:  1477-7819     ISO Abbreviation:  World J Surg Oncol     Publication Date:  2011  
Date Detail:
Created Date:  2011-08-29     Completed Date:  2012-01-03     Revised Date:  2013-06-28    
Medline Journal Info:
Nlm Unique ID:  101170544     Medline TA:  World J Surg Oncol     Country:  England    
Other Details:
Languages:  eng     Pagination:  76     Citation Subset:  IM    
Affiliation:
Department of Lung Cancer Surgery, Tianjin Key Laboratory of Lung Cancer Metastasis and Tumor Microenvironment, Tianjin Lung Cancer Institute, Tianjin Medical University General Hospital, China. huntercj2004@yahoo.com
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Biopsy
Diagnosis, Differential
Follow-Up Studies
Humans
Leiomyoma / diagnosis*,  surgery
Male
Middle Aged
Pleural Neoplasms / diagnosis*,  surgery
Radiography, Thoracic
Thoracotomy / methods*
Tomography, X-Ray Computed
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Full Text
Journal Information
Journal ID (nlm-ta): World J Surg Oncol
ISSN: 1477-7819
Publisher: BioMed Central
Article Information
Download PDF
Copyright ©2011 Qiu et al; licensee BioMed Central Ltd.
open-access:
Received Day: 19 Month: 4 Year: 2011
Accepted Day: 14 Month: 7 Year: 2011
collection publication date: Year: 2011
Electronic publication date: Day: 14 Month: 7 Year: 2011
Volume: 9First Page: 76 Last Page: 76
ID: 3163191
Publisher Id: 1477-7819-9-76
PubMed Id: 21752306
DOI: 10.1186/1477-7819-9-76

Primary Leiomyoma of the pleura
Xiaoming Qiu1 Email: maxq1982@yahoo.com.cn
Daxin Zhu1 Email: zhuda20036@163.com
Sen Wei1 Email: liuqian@tjmugh.com.cn
Gang Chen1 Email: weisen1566@163.com
Jun Chen1 Email: huntercj2004@yahoo.com
Qinghua Zhou1 Email: zhouqh1016@yahoo.com.cn
1Department of Lung Cancer Surgery, Tianjin Key Laboratory of Lung Cancer Metastasis and Tumor Microenvironment, Tianjin Lung Cancer Institute, Tianjin Medical University General Hospital, Tianjin 300052, China

Introduction

Leiomyomas are benign smooth muscle tumors that are commonly encountered in the urogenital tract, occasionally in the gastrointestinal tract, and rarely in the respiratory tract [1]. However, leiomyomas originating from the pleura are extremely rare. To our knowledge, only 8 cases have been published up to the present time. Here, we present the first primary pleural leiomyoma in China.


Case report

A 45-year-old man without any significant past history was admitted to our department complaining of right chest pain persisting for 3 days. A mass was seen in the right middle lung field on chest roentgenogram (Figure 1A). However, physical examination was unremarkable. Computed tomography showed a solid, round pleural mass measuring 5.9 cm × 8 cm × 6.2 cm located in the right anterior chest wall, with " heterogeneous density and calcification. It was well capsulated and compressed the lung parenchyma without any sign of infiltration of the lung or chest wall (Figure 1B).

The patient underwent a right posterolateral thoracotomy. A giant, well-capsulated smooth-surfaced tumor was observed in the anterior chest wall. It was easily resected en-bloc with surrounding tissue. Grossly, the tumor measured 9 cm × 6 cm × 5 cm and was covered with pleura. The cut tumor was solid white with cystic cavities. Pathological examination revealed a proliferation of interlaced fascicles of spindle cells showing moderate atypia and less than 1 mitotic figure per 50 high power fields (Figure 2). Immunohistochemistry revealed diffuse and strong staining for both smooth muscle actin (SMA) and desmin (Figure 2). Tumor tissue stained negative for estrogen receptor, progesterone receptor, CD117, and HMB45, and was weakly positive for S-100 protein (data not shown).

The patient had an uneventful recovery, and there has been no sign of recurrence 15 months after surgery. Since the malignant potential of the tumor could not be determined, close follow-up of the patient was advised.


Discussion

Primary intrathoracic soft tissue tumors are unusual. They can originate from the upper or lower respiratory tract or from the mediastinum. The differential diagnosis for pleural spindle cell neoplasms includes solitary fibrous tumor, smooth muscle tumor, spindle cell carcinoma, thymoma, sarcomatoid variant of mesothelioma, and leiomyoid variant of mesothelioma [2-5]. Leiomyomas commonly originating from urogenital tract and gastrointestinal tract are most benign smooth muscle tumors, and rarely originates from respiratory tract and pleura. So far, there were only 8 primary pleural leiomyomas reported in the world [1,6-11]. Table 1 summarizes patient and tumor characteristics of the 8 previously described cases and our case. Of these cases, 6 were asymptomatic and 3 had nonspecific chest pain related to tumor size and location. The tumor appears to occur more frequently in young to middle-aged females (6 of nine cases).

Although this leiomyoma of the pleura appeared benign, with a smooth, well-capsulated surface and unremarkable histologic findings, it has a low but definite malignant potential. Pleural leiomyomas may increase in size with local invasion to the mediastinum and may not be possible to resect completely [7]. They may even metastasize or disseminate through the needle tract years after a transthoracic fine-needle biopsy [1]. Computed tomography-guided transthoracic fine-needle aspiration (FNA) of chest wall tumors is preferred by oncologists, in order to obtain an accurate preoperative tissue diagnosis by histopathological examination [12,13]. Although FNA can be easily performed for most chest tumors, with minimal damage to the primary tumor and low rates of complications, to avoid needle seeding, we believe that FNA should not be performed if the tumor can be resected completely. It should only be performed when the tumor is unresectable or the patient refuses surgery, in order to allow pathologic diagnosis for further medical treatment.

Most tumors can be completely resected if the contrast-enhanced chest CT scan shows a well-capsulated pleural mass with minimal invasion of the adjacent organs, and the patient does not have signs of invasion, such as very severe pain. In general, most primary pleural leiomyomas can be easily and completely resected. If the tumor is small and localized, complete resection can be achieved with minimally invasive surgery such as video-assisted thoracic surgery (VATS) [8,9,14]. In addition, the prognosis is fairly good for patients in whom the tumor is completely resected. The presence of smooth muscle fibers without signs of malignancy (pleomorphism, mitotic figures, and poor differentiation) can be confirmed by hematoxylin and eosin (H&E) staining. Immunohistochemical staining should be positive for SMA, vimentin, desmin, and HH35 soft muscle protein [1,13]. The histological features of H&E-stained tissue sections plus positive staining for SMA and desmin provide unambiguous evidence for the diagnosis of primary pleural leiomyoma.


Conclusion

In summary, because primary pleural leiomyoma is an extremely rare tumor with low malignant potential, complete resection and close follow-up is advised. Transthoracic fine-needle biopsy is contraindicated if it is possible that the tumor can be completely resected.


Consent

Written informed consent was obtained from the patient for publication of this Case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.


Competing interests

The authors declare that they have no competing interests.


Authors' contributions

XQ, DZ, JC and QZ did the surgery, SW and GC collected the data. XQ, JC and QZ wrote the article. All authors read and approved the final manuscript.


Acknowledgements

This work was supported by grants from National Natural Science Foundation of China (30670922), "863"(2006AA02A401), "973"(2010CB529405), Major Project of Tianjin Sci-Tech Support Program (07SYSYSF05000), and Key Project of Tianjin Sci-Tech Support Program (06YFSZSF05300) to Qinghua Zhou.


References
Proca DM,Ross P Jr,Pratt J,Frankel WL,Smooth muscle tumor of the pleura. A case report and review of the literatureArch Pathol Lab MedYear: 20001241688169211079027
Khalifa MA,Montgomery EA,Azumi N,Gomes MN,Zeman RK,Min KW,Lack EE,Solitary fibrous tumors: a series of lesions, some in unusual sitesSouth Med JYear: 19979079379910.1097/00007611-199708000-000059258305
Gannon BR,O'Hara CD,Reid K,Isotalo PA,Solitary fibrous tumor of the anterior mediastinum: a rare extrapleural neoplasmTumoriYear: 20079350851018038888
Xue X,Chen J,Ma W,Zhu D,Zhang W,Chen G,Wei S,Zhou Q,Mediastinal solitary fibrous tumor with right diaphragm invasion: report of a caseSurg TodayYear: 20093933233410.1007/s00595-008-3841-419319642
Van Kolen KPL,Heyman S,Pauwels P,Van Schil P,Prognostic factors and genetic markers in thymomaThoracic CancerYear: 2010113314010.1111/j.1759-7714.2010.00028.x
Tanaka T,Adachi A,Iwata S,Nishimura Y,Tanaka Y,Kakegawa T,[A case of leiomyoma of the chest wall]Nippon Kyobu Geka Gakkai ZasshiYear: 199240172117241402189
Moran CA,Suster S,Koss MN,Smooth muscle tumours presenting as pleural neoplasmsHistopathologyYear: 19952722723410.1111/j.1365-2559.1995.tb00214.x8522286
Mochizuki H,Okada T,Yoshizawa H,Suzuki E,Gejyo F,[A case of primary pleural leiomyoma]Nihon Kokyuki Gakkai ZasshiYear: 20044262562815357263
Nose N,Inoue M,Kodate M,Kawaguchi M,Yasumoto K,Leiomyoma originating from the extrapleural tissue of the chest wallJpn J Thorac Cardiovasc SurgYear: 20065424224510.1007/PL0002224416813105
Turhan KCA,Cagirici U,Leiomyoma: an unusual pleural tumor:report of a caseTurk Resp JYear: 200895355
Rodriguez PM,Freixinet JL,Plaza ML,Camacho R,Unusual primary pleural leiomyomaInteract Cardiovasc Thorac SurgYear: 20101044144210.1510/icvts.2009.21938620040476
Karapolat S,Leiomyoma: an Unusual Pleural Tumor: Letters to the EditorTurk Resp JYear: 20089193
Al-Daraji WI,Salman WD,Nakhuda Y,Zaman F,Eyden B,Primary smooth muscle tumor of the pleura: a clinicopathological case report with ultrastructural observations and a review of the literatureUltrastruct PatholYear: 20052938939810.1080/01913129094570916257865
Lv X,Luo WZ,Wang YQ,Chen X,Tu ZL,Bilateral thoracotomy for removal of uncommon postmediastinal multi-schwannomasThoracic CancerYear: 2010113013210.1111/j.1759-7714.2010.00022.x

Figures

[Figure ID: F1]
Figure 1 

Chest images (A) Chest radiograph. A mass is seen in the right middle lung field on chest roentgenogram; (B) Chest contrast enhanced computed tomography scans. A solid, round pleural mass is seen in the right anterior chest wall, with heterogeneous density and calcification. It is well capsulated and compresses the lung parenchyma without any sign of infiltration of lung or chest wall.



[Figure ID: F2]
Figure 2 

Hematoxylin-and-eosin staining reveals a proliferation of interlaced fascicles of spindle cells showing moderate atypia and less than 1/50 mitotic figures per high power field. Immunohistochemical staining reveals diffuse and strongly positive reactions with both anti-SMA and -desmin antibodies.



Tables
[TableWrap ID: T1] Table 1 

Clinical features of published case reports of primary pleural leiomyoma


Case Author Gender/age Clinical manifestations Clinical course Tumor size (cm) Follow-up after operation
1 Tanaka T et al [6] F/40 Asymptomatic Complete resection 3,5 × 3,0 17 months
Alive without recurrence

2 Moran CA et al [7] F/21 Asymptomatic, large left pleural tumor involving diaphragm Too large for complete resection Multiple fragments of firm, grey tissues 4 months
Alive

3 Moran CA et al [7] F/23 Asymptomatic,
large mass arising from the right pleura
Too large for complete resection 10.0 × 9.0 × 5.5 6 months
Alive

4 Proca DM et al [1] M/32 Asymptomatic Resected 4 years after needle biopsy, when enlarged and invading the chest wall 4.3 × 7.0 12 months.
Alive without recurrence

5 Mochizuki H et al [8] M/33 Asymptomatic Complete resection with VATS 3 × 2 Unknown

6 Nose N et al [9] F/55 Asymptomatic Complete resection with VATS 1.5 × 1.5 26 months
Alive without recurrence

7 Turhan K et al [10] F/50 Chest pain Complete resection 4.0 × 4.0 53 months
Alive without recurrence

8 Rodriguez, PM [11] F/48 Chest pain Complete resection 18 × 14 × 11 18 months
Alive without recurrence

9 Our case M/45 Chest pain Complete resection 9 × 6 × 5 15 months
Alive without recurrence

VATS, video-assisted thoracic surgery.



Article Categories:
  • Case Report

Keywords: Pleural tumor, Leiomyoma, Smooth muscle tumor.

Previous Document:  Peptide binding prediction for the human class II MHC allele HLA-DP2: a molecular docking approach.
Next Document:  Prevalence of metabolic syndrome in Murcia Region, a southern European Mediterranean area with low c...