Document Detail

Primary hyperparathyroidism in pregnancy: a diagnostic and therapeutic challenge.
MedLine Citation:
PMID:  20469964     Owner:  NLM     Status:  In-Process    
The risk of severe complications arising from primary hyperparathyroidism (pHPT) is increased during pregnancy. Gestational pHPT often goes undiagnosed, and by the time it is diagnosed, a majority of women have endured one or more failed pregnancies. During pregnancy, active transport of calcium ions from the mother to the fetus leads to suppression of the fetal parathyroids. When the prenatal pool of calcium is depleted, the newborn may develop neonatal hypocalcemic tetany. The mother, in turn, may suffer from worsening hypercalcemia and a hypercalcemic crisis after delivery. Awareness and confirmation of the diagnosis may be crucial for the outcome. The only definitive treatment of pHPT is parathyroidectomy, which should be recommended in most cases. Our two cases illustrate both the importance of and the difficulty in detecting pHPT during pregnancy, as well as some of the serious complications that may occur during pregnancy and after delivery.
I-L Nilsson; N Adner; E Reihnér; C Palme-Kilander; G Edstrom; M Degerblad
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of women's health (2002)     Volume:  19     ISSN:  1931-843X     ISO Abbreviation:  J Womens Health (Larchmt)     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-06-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101159262     Medline TA:  J Womens Health (Larchmt)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1117-21     Citation Subset:  IM    
Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.
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