Document Detail


Primary Follicular Dendritic Cell Sarcoma of the Thyroid Gland Coexisting With Hashimoto's Thyroiditis.
MedLine Citation:
PMID:  19448067     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Follicular dendritic cell (FDC) sarcoma, especially of extranodal origin, is an extremely rare malignancy of FDC origin, with only 1 case previously documented in the thyroid. The authors report the case of a 58-year-old female who presented with a painless mass in her neck. The neoplastic cells expressed monocyte/macrophage-specific marker CD68 (KP-1) and lysozymes and the dendritic cell-associated antigens CD35 and Fascin but was negative for CD1a, CD21, and CD23, most consistent with a diagnosis of FDC sarcoma. BIOMED-2 multiplex polymerase chain reaction analysis showed B-cell clonality in both tumor and its adjacent coexisting Hashimoto's thyroiditis. To the authors' knowledge, this is the first report of a rare entity of FDC sarcoma primarily involving the thyroid gland coexisting with Hashimoto's thyroiditis.
Authors:
Lu Yu; Shou Jing Yang
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Publication Detail:
Type:  Journal Article     Date:  2009-05-15
Journal Detail:
Title:  International journal of surgical pathology     Volume:  19     ISSN:  1940-2465     ISO Abbreviation:  Int. J. Surg. Pathol.     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-08-31     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9314927     Medline TA:  Int J Surg Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  502-5     Citation Subset:  IM    
Affiliation:
1Pathology, Xi Jing Hospital, 4th Military Medical University, Xi'an, Shaanxi 710032, China.
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