Document Detail

Primary Candida meningitis and chronic granulomatous disease.
MedLine Citation:
PMID:  3706396     Owner:  NLM     Status:  MEDLINE    
The occurrence of two rare entities in a single patient can be fortuitous or may signify some deeper relationship. A young boy was recently treated for primary Candida meningitis. Autopsy findings suggested to an experienced pathologist the presence of chronic granulomatous disease (CGD), unrecognized during his life. The patient's identical twin brother was tested and found to have the typical laboratory features of CGD. The literature on Candida meningitis was reviewed and 15 cases were discovered that apparently arose in the absence of recognized predisposing causes. All but one of these cases occurred in males, and most occurred during the first three decades of life. The case reports and literature review presented herein suggest that CGD should be suspected when a case of "primary" Candida meningitis is encountered.
J Fleischmann; J A Church; R I Lehrer
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of the medical sciences     Volume:  291     ISSN:  0002-9629     ISO Abbreviation:  Am. J. Med. Sci.     Publication Date:  1986 May 
Date Detail:
Created Date:  1986-06-10     Completed Date:  1986-06-10     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370506     Medline TA:  Am J Med Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  334-41     Citation Subset:  AIM; IM    
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MeSH Terms
Candidiasis / etiology*,  immunology
Diseases in Twins*
Granulomatous Disease, Chronic / complications*,  genetics,  immunology
Meningitis / etiology*,  immunology,  microbiology
Twins, Monozygotic
Grant Support

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