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Primary Amebic Meningoencephalitis: A Case Report and Literature Review.
MedLine Citation:
PMID:  22391923     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
ABSTRACT: Primary amebic meningoencephalitis (PAM) is a rare but nearly always fatal disease caused by infection with Naegleria fowleri, a thermophilic, free-living ameba found in freshwater environments. Cases of N. fowleri infection have been reported from many of the southern-tier states in the United States, with Florida and Texas disproportionately represented among them. Primary amebic meningoencephalitis presents clinically in a fashion that may be indistinguishable from bacterial and viral meningitis. Unfortunately, because the disease is so rare, PAM is often excluded from the differential diagnosis of children with meningitis resulting in delayed diagnostic and therapeutic efforts.Pediatric acute care practitioners in emergency departments, general pediatric wards, and critical care units, especially those practicing in the southern United States, should be familiar with the risk factors for acquisition of PAM, its clinical presentation, and the fact that common empiric treatment of bacterial meningitis will not treat N. fowleri. Herein, we present the case of an adolescent who died of PAM and review the (a) epidemiology, (b) pathophysiology, (c) available diagnostic modalities, (d) treatment options, and (e) outcomes of patients treated for N. fowleri infection of the central nervous system.
Authors:
Christina Lopez; Phillip Budge; Jimmy Chen; Suzanne Bilyeu; Ayesha Mirza; Haidee Custodio; Jose Irazuzta; Govinda Visvesvara; Kevin J Sullivan
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Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  Pediatric emergency care     Volume:  28     ISSN:  1535-1815     ISO Abbreviation:  -     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-3-6     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8507560     Medline TA:  Pediatr Emerg Care     Country:  -    
Other Details:
Languages:  ENG     Pagination:  272-276     Citation Subset:  -    
Affiliation:
From the *University of Florida, Jacksonville, FL; †Division of Parasitic Diseases and Malaria, Center for Global Health, Centers for Disease Control and Prevention, Atlanta, GA; ‡Division of Hospital Pediatrics, University of Florida; §Division of Hospital Pediatrics, Nemours Children's Clinic; ∥Division of Pediatric Infectious Disease, University of Florida; ¶Division of Pediatric Critical Care Medicine, University of Florida, Jacksonville, FL; #Divisions of Foodborne, Waterborne and Environmental Diseases, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA; and **Department of Pediatric Anesthesia and Critical Care Medicine, Nemours Children's Clinic, Jacksonville, FL.
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