Document Detail

Primaquine prophylaxis against malaria in nonimmune Colombian soldiers: efficacy and toxicity. A randomized, double-blind, placebo-controlled trial.
MedLine Citation:
PMID:  9696733     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Primaquine had a prophylactic efficacy of 90% to 95% against infection with Plasmodium falciparum and P. vivax in Indonesian settlers. OBJECTIVE: To evaluate the efficacy of primaquine prophylaxis for protecting nonimmune persons from malaria. DESIGN: Randomized, double-blind, placebo-controlled field study. SETTING: A malaria-endemic area in Colombia. PATIENTS: 176 healthy, young, nonimmune adult male soldiers. INTERVENTION: Primaquine, 30 mg/d, or matching placebo during 15 weeks of patrol in the endemic area and 1 week afterward. MEASUREMENTS: Symptomatic parasitemia was determined over the 16-week intervention period and for 3 weeks in base camp. RESULTS: Protective efficacy in the primaquine group (122 participants) was 89% (95% CI, 75% to 96%) against all types of malaria, 94% (CI, 78% to 99%) against P. falciparum malaria, and 85% (CI, 57% to 95%) against P. vivax malaria. Six primaquine recipients had mild to moderate gastrointestinal distress, and three had severe distress. CONCLUSIONS: For prophylaxis against P. falciparum malaria, primaquine has an efficacy and toxicity competitive with those of standard agents. A potential advantage of primaquine is that prophylaxis may be discontinued 1 week after the recipient has left the endemic area.
J Soto; J Toledo; M Rodriquez; J Sanchez; R Herrera; J Padilla; J Berman
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Annals of internal medicine     Volume:  129     ISSN:  0003-4819     ISO Abbreviation:  Ann. Intern. Med.     Publication Date:  1998 Aug 
Date Detail:
Created Date:  1998-08-05     Completed Date:  1998-08-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372351     Medline TA:  Ann Intern Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  241-4     Citation Subset:  AIM; IM    
Universidad Militar Nueva Granada, Consorcio de Investigaciones Bioclinicas, Dirección de Sanidad Ejercito, Bogota, Columbia.
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MeSH Terms
Antimalarials / adverse effects*,  therapeutic use*
Double-Blind Method
Gastrointestinal Diseases / chemically induced
Malaria, Falciparum / prevention & control*
Malaria, Vivax / prevention & control*
Military Personnel*
Patient Compliance
Patient Dropouts
Primaquine / adverse effects*,  therapeutic use*
Reg. No./Substance:
0/Antimalarials; 90-34-6/Primaquine
Comment In:
Ann Intern Med. 1999 Mar 16;130(6):536; author reply 536-7   [PMID:  10075625 ]
Ann Intern Med. 1999 Mar 16;130(6):536-7   [PMID:  10075624 ]

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