| Primaquine prophylaxis against malaria in nonimmune Colombian soldiers: efficacy and toxicity. A randomized, double-blind, placebo-controlled trial. | |
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MedLine Citation:
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PMID: 9696733 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Primaquine had a prophylactic efficacy of 90% to 95% against infection with Plasmodium falciparum and P. vivax in Indonesian settlers. OBJECTIVE: To evaluate the efficacy of primaquine prophylaxis for protecting nonimmune persons from malaria. DESIGN: Randomized, double-blind, placebo-controlled field study. SETTING: A malaria-endemic area in Colombia. PATIENTS: 176 healthy, young, nonimmune adult male soldiers. INTERVENTION: Primaquine, 30 mg/d, or matching placebo during 15 weeks of patrol in the endemic area and 1 week afterward. MEASUREMENTS: Symptomatic parasitemia was determined over the 16-week intervention period and for 3 weeks in base camp. RESULTS: Protective efficacy in the primaquine group (122 participants) was 89% (95% CI, 75% to 96%) against all types of malaria, 94% (CI, 78% to 99%) against P. falciparum malaria, and 85% (CI, 57% to 95%) against P. vivax malaria. Six primaquine recipients had mild to moderate gastrointestinal distress, and three had severe distress. CONCLUSIONS: For prophylaxis against P. falciparum malaria, primaquine has an efficacy and toxicity competitive with those of standard agents. A potential advantage of primaquine is that prophylaxis may be discontinued 1 week after the recipient has left the endemic area. |
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Authors:
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J Soto; J Toledo; M Rodriquez; J Sanchez; R Herrera; J Padilla; J Berman |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Annals of internal medicine Volume: 129 ISSN: 0003-4819 ISO Abbreviation: Ann. Intern. Med. Publication Date: 1998 Aug |
Date Detail:
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Created Date: 1998-08-05 Completed Date: 1998-08-05 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372351 Medline TA: Ann Intern Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 241-4 Citation Subset: AIM; IM |
Affiliation:
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Universidad Militar Nueva Granada, Consorcio de Investigaciones Bioclinicas, Dirección de Sanidad Ejercito, Bogota, Columbia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Antimalarials / adverse effects*, therapeutic use* Colombia Double-Blind Method Gastrointestinal Diseases / chemically induced Humans Malaria, Falciparum / prevention & control* Malaria, Vivax / prevention & control* Male Military Personnel* Patient Compliance Patient Dropouts Primaquine / adverse effects*, therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Antimalarials; 90-34-6/Primaquine |
| Comments/Corrections | |
Comment In:
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Ann Intern Med. 1999 Mar 16;130(6):536; author reply 536-7
[PMID:
10075625
]
Ann Intern Med. 1999 Mar 16;130(6):536-7 [PMID: 10075624 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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