Document Detail

Primaquine and lysosomotropic amines inhibit malaria sporozoite entry into human liver cells.
MedLine Citation:
PMID:  3887157     Owner:  NLM     Status:  MEDLINE    
The binding and entry of Plasmodium berghei sporozoites to human hepatoma HepG2 cells is inhibited in a dose-dependent manner by primaquine, chloroquine and other lysosomotropic amines. The site of action of these agents appears to be the hepatoma cell itself, not the sporozoite. While this inhibitory effect of primaquine is rapidly reversible, the precise mechanism responsible for this effect is not presently known.
A L Schwartz; M R Hollingdale
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Molecular and biochemical parasitology     Volume:  14     ISSN:  0166-6851     ISO Abbreviation:  Mol. Biochem. Parasitol.     Publication Date:  1985 Mar 
Date Detail:
Created Date:  1985-05-30     Completed Date:  1985-05-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8006324     Medline TA:  Mol Biochem Parasitol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  305-11     Citation Subset:  IM    
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MeSH Terms
Amines / pharmacology
Cell Line
Chloroquine / pharmacology
Liver / parasitology*
Lysosomes / drug effects
Malaria / drug therapy*,  parasitology
Plasmodium berghei / drug effects
Primaquine / pharmacology*
Reg. No./Substance:
0/Amines; 54-05-7/Chloroquine; 90-34-6/Primaquine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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