Document Detail


Prilling for the development of multi-particulate colon drug delivery systems: Pectin vs. pectin-alginate beads.
MedLine Citation:
PMID:  23218307     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
This paper proposes a multi-particulate drug delivery system produced by prilling technique in combination with an enteric coating. Optimization of process parameters, such as feed viscosity at nozzle, selection of cross-linker, pH of the gelling solution and cross-linking time, allows to obtain beads with strong gelled matrix. Results showed that dextran/piroxicam beads demonstrated high encapsulation efficiency, very narrow dimensional distribution and high sphericity. Coated beads retained shape and narrow size distribution of the uncoated particles. Moreover, the strength of the produced Zn(2+)-pectinate beads allows to reduce Eudragit(®) coating thickness. Piroxicam loaded multi-particulate systems show an interesting prolonged drug release in intestinal fluids. Hence, such platforms could be proposed for the treatment of inflammatory bowel diseases.
Authors:
Giulia Auriemma; Teresa Mencherini; Paola Russo; Mariateresa Stigliani; Rita P Aquino; Pasquale Del Gaudio
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Publication Detail:
Type:  Journal Article     Date:  2012-10-04
Journal Detail:
Title:  Carbohydrate polymers     Volume:  92     ISSN:  1879-1344     ISO Abbreviation:  Carbohydr Polym     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-12-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8307156     Medline TA:  Carbohydr Polym     Country:  England    
Other Details:
Languages:  eng     Pagination:  367-73     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
Affiliation:
Department of Pharmaceutical and Biomedical Sciences, University of Salerno, I-84084 Fisciano (SA), Italy.
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