Document Detail


Previous use of quinolones: a surrogate marker for first line anti-tuberculosis drugs resistance in HIV-infected patients?
MedLine Citation:
PMID:  22552455     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: Drug resistant Mycobacterium tuberculosis causes much higher rates of treatment toxicity, failure or relapse, and mortality. We determined the drug resistant profile of Mycobacterium tuberculosis strains isolated from a population of HIV-infected patients in southern Brazil and studied the potential factors associated with resistance.
METHODS: We conducted a retrospective cohort study to determine the resistance profile of Mycobacterium tuberculosis isolated from HIV-infected patients and factors that could be associated with resistance from 2000 to 2005.
RESULTS: 236 patients were included in the study. Resistance to at least one drug was observed in 32 (14.6%) isolates, and multi-drug resistance was observed in 4 (1.82%) isolates. On multivariate analysis, previous use of tuberculostatics and quinolones were related to any first-line drug resistance.
CONCLUSIONS: In our study, previous quinolone use was significantly associated to first-line anti-TB drugs resistance. Multi-drug-resistant tuberculosis (MDR-TB) is a major problem worldwide, and we believe quinolones should be used with caution in settings where TB is endemic.
Authors:
Caroline Deutschendorf; Luciano Z Goldani; Rodrigo Pires dos Santos
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases     Volume:  16     ISSN:  1678-4391     ISO Abbreviation:  Braz J Infect Dis     Publication Date:    2012 Mar-Apr
Date Detail:
Created Date:  2012-05-03     Completed Date:  2013-03-29     Revised Date:  2013-08-05    
Medline Journal Info:
Nlm Unique ID:  9812937     Medline TA:  Braz J Infect Dis     Country:  Brazil    
Other Details:
Languages:  eng     Pagination:  142-5     Citation Subset:  IM    
Affiliation:
Infectious Diseases Section, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, RS, Brazil.
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MeSH Terms
Descriptor/Qualifier:
Adult
Antitubercular Agents / pharmacology*,  therapeutic use
Biological Markers
Cohort Studies
Female
HIV Infections / microbiology*
Humans
Male
Microbial Sensitivity Tests
Multivariate Analysis
Mycobacterium tuberculosis / drug effects*,  isolation & purification
Quinolones / therapeutic use*
Retrospective Studies
Tuberculosis, Multidrug-Resistant / microbiology*
Chemical
Reg. No./Substance:
0/Antitubercular Agents; 0/Biological Markers; 0/Quinolones

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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