Document Detail

Previous prenatal loss as a predictor of perinatal depression and anxiety.
MedLine Citation:
PMID:  21372060     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Prenatal loss, the death of a fetus/child through miscarriage or stillbirth, is associated with significant depression and anxiety, particularly in a subsequent pregnancy.
AIMS: This study examined the degree to which symptoms of depression and anxiety associated with a previous loss persisted following a subsequent successful pregnancy.
METHOD: Data were derived from the Avon Longitudinal Study of Parents and Children cohort, a longitudinal cohort study in the west of England that has followed mothers from pregnancy into the postnatal period. A total of 13,133 mothers reported on the number and conditions of previous perinatal losses and provided self-report measures of depression and anxiety at 18 and 32 weeks' gestation and at 8 weeks and 8, 21 and 33 months postnatally. Controls for pregnancy outcome and obstetric and psychosocial factors were included.
RESULTS: Generalised estimating equations indicated that the number of previous miscarriages/stillbirths significantly predicted symptoms of depression (β = 0.18, s.e. = 0.07, P<0.01) and anxiety (β = 0.14, s.e. = 0.05, P<0.01) in a subsequent pregnancy, independent of key psychosocial and obstetric factors. This association remained constant across the pre- and postnatal period, indicating that the impact of a previous prenatal loss did not diminish significantly following the birth of a healthy child.
CONCLUSIONS: Depression and anxiety associated with a previous prenatal loss shows a persisting pattern that continues after the birth of a subsequent (healthy) child. Interventions targeting women with previous prenatal loss may improve the health outcomes of women and their children.
Emma Robertson Blackmore; Denise Côté-Arsenault; Wan Tang; Vivette Glover; Jonathan Evans; Jean Golding; Thomas G O'Connor
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2011-03-03
Journal Detail:
Title:  The British journal of psychiatry : the journal of mental science     Volume:  198     ISSN:  1472-1465     ISO Abbreviation:  Br J Psychiatry     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-04-28     Completed Date:  2011-07-21     Revised Date:  2014-09-19    
Medline Journal Info:
Nlm Unique ID:  0342367     Medline TA:  Br J Psychiatry     Country:  England    
Other Details:
Languages:  eng     Pagination:  373-8     Citation Subset:  IM    
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MeSH Terms
Abortion, Spontaneous / epidemiology,  psychology*
Alcohol Drinking / epidemiology
Anxiety / epidemiology*
Depression, Postpartum / epidemiology*,  psychology
England / epidemiology
Epidemiologic Methods
Middle Aged
Mother-Child Relations
Mothers / psychology
Postpartum Period / psychology
Pregnancy / psychology*
Smoking / epidemiology
Stillbirth / epidemiology,  psychology*
Young Adult
Grant Support
092731//Wellcome Trust; G9815508//Medical Research Council; K23 MH080290/MH/NIMH NIH HHS; K23 MH080290/MH/NIMH NIH HHS; K23 MH080290-04/MH/NIMH NIH HHS; R01 MH073842/MH/NIMH NIH HHS; R01 MH073842/MH/NIMH NIH HHS; R01 MH073842-05/MH/NIMH NIH HHS; //Medical Research Council; //Wellcome Trust

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