Document Detail


Previous pregnancy as a protective factor against death from melanoma.
MedLine Citation:
PMID:  65563     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Examination of the case-records of women presenting to the Melanoma Unit at Sydney Hospital over the period 1961-71 has shown that women with pregnancies before the development of melanoma had a better survival-rate from melanoma than women without previous pregnancies. The known presence of fetal antigens on melanoma cells and immunisation against fetal antigens during pregnancy suggest an immunological explanation for these results. Exposure to fetal antigens during pregnancy may protect against the dissemination of melanoma cells bearing similar fetal antigens and thus increase the survival-rate. The incidence of melanoma in males and females was approximately equal, which suggests that immune responses to tumour-associated antigens may be more effective in preventing spread of tumours than in preventing their occurrence.
Authors:
P Hersey; G Morgan; D E Stone; W H McCarthy; G W Milton
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Lancet     Volume:  1     ISSN:  0140-6736     ISO Abbreviation:  Lancet     Publication Date:  1977 Feb 
Date Detail:
Created Date:  1977-04-25     Completed Date:  1977-04-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2985213R     Medline TA:  Lancet     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  451-2     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Age Factors
Antibody Formation*
Antigens*
Antigens, Neoplasm*
Female
Fetus / immunology*
Humans
Male
Melanoma / immunology,  mortality*,  pathology
Middle Aged
Pregnancy*
Retrospective Studies
Skin Neoplasms / immunology,  mortality*,  pathology
Time Factors
Chemical
Reg. No./Substance:
0/Antigens; 0/Antigens, Neoplasm

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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