| Previous pregnancy as a protective factor against death from melanoma. | |
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MedLine Citation:
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PMID: 65563 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Examination of the case-records of women presenting to the Melanoma Unit at Sydney Hospital over the period 1961-71 has shown that women with pregnancies before the development of melanoma had a better survival-rate from melanoma than women without previous pregnancies. The known presence of fetal antigens on melanoma cells and immunisation against fetal antigens during pregnancy suggest an immunological explanation for these results. Exposure to fetal antigens during pregnancy may protect against the dissemination of melanoma cells bearing similar fetal antigens and thus increase the survival-rate. The incidence of melanoma in males and females was approximately equal, which suggests that immune responses to tumour-associated antigens may be more effective in preventing spread of tumours than in preventing their occurrence. |
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Authors:
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P Hersey; G Morgan; D E Stone; W H McCarthy; G W Milton |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Lancet Volume: 1 ISSN: 0140-6736 ISO Abbreviation: Lancet Publication Date: 1977 Feb |
Date Detail:
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Created Date: 1977-04-25 Completed Date: 1977-04-25 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 2985213R Medline TA: Lancet Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 451-2 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Age Factors Antibody Formation* Antigens* Antigens, Neoplasm* Female Fetus / immunology* Humans Male Melanoma / immunology, mortality*, pathology Middle Aged Pregnancy* Retrospective Studies Skin Neoplasms / immunology, mortality*, pathology Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Antigens; 0/Antigens, Neoplasm |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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