Document Detail


Previous cytomegalovirus infection and risk of coronary thrombotic events after stent placement.
MedLine Citation:
PMID:  10618297     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Cytomegalovirus (CMV) infection induces upregulation of tissue factor and loss of anticoagulants, including thrombomodulin, prostacyclin, and tissue plasminogen activator. CMV infection may thereby increase the procoagulant properties of coronary artery plaques. This prospective study investigated the effect of previous CMV infection on the early hazard of coronary stent placement. METHODS AND RESULTS: In 551 consecutive patients with successful coronary stent placement, we determined CMV IgG titers. The end point was the composite rate of death, nonfatal Q-wave myocardial infarction, and urgent reintervention during 30-day follow-up. The study population represented the entire spectrum of coronary stenting; an acute coronary syndrome was present in 50% of the patients. A positive CMV IgG titer (>/=1/230) was found in 340 patients (62%). Of these, 10 reached the end point during 30-day follow-up (2 deaths, 4 infarctions, 4 urgent reinterventions). In the group with negative CMV titer, thrombotic events did not occur (P=0.014 versus group with positive CMV titers). After correction for pertinent covariables, a significant relation between positive CMV titer and the 30-day end point prevailed (P<0.001). CONCLUSIONS: Previous CMV infection may increase the risk of coronary thrombotic events after stent placement.
Authors:
F J Neumann; A Kastrati; T Miethke; G Pogatsa-Murray; M Seyfarth; A Schömig
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Circulation     Volume:  101     ISSN:  0009-7322     ISO Abbreviation:  Circulation     Publication Date:    2000 Jan 4-11
Date Detail:
Created Date:  2000-02-24     Completed Date:  2000-02-24     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  11-3     Citation Subset:  AIM; IM    
Affiliation:
Deutsches Herzzentrum, Technischen Universität München, Munich, Germany. neumann@med1.med.tu-muenchen.de
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MeSH Terms
Descriptor/Qualifier:
Aged
Angioplasty, Balloon
Antibodies, Viral / blood
Cohort Studies
Coronary Disease / therapy*
Coronary Thrombosis / epidemiology*,  etiology
Cytomegalovirus Infections / complications*
Female
Humans
Immunoglobulin G / blood
Male
Middle Aged
Myocardial Infarction / mortality,  physiopathology,  therapy
Risk Factors
Stents / adverse effects*
Chemical
Reg. No./Substance:
0/Antibodies, Viral; 0/Immunoglobulin G

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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